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MHC class II-negative severe combined immunodeficiency [1 record]
Record 1 - internal organization data 1993-02-11
Record 1, English
Record 1, Subject field(s)
- Immunology
Record 1, Main entry term, English
- MHC class II-negative severe combined immunodeficiency 1, record 1, English, MHC%20class%20II%2Dnegative%20severe%20combined%20immunodeficiency
Record 1, Abbreviations, English
Record 1, Synonyms, English
Record 1, Textual support, English
Record number: 1, Textual support number: 1 DEF
An inherited severe combined immunodeficiency (SCID) in man ... characterized by an absence of membrane expression of HLA (human leucocyte antigen) class II molecules and a decreased expression of HLA class I molecules on peripheral blood leucocytes. These patients have a profound defect of antibody production and off cell-mediated immunity leading to infections which are often lethal. Synthesis of all HLA class II molecules was found absent and synthesis of HLA class I molecules decreased in patient leucocytes and PHA-induced blasts. 1, record 1, English, - MHC%20class%20II%2Dnegative%20severe%20combined%20immunodeficiency
Record number: 1, Textual support number: 1 OBS
According to World Health Organization's nomenclature. 2, record 1, English, - MHC%20class%20II%2Dnegative%20severe%20combined%20immunodeficiency
Record 1, French
Record 1, Domaine(s)
- Immunologie
Record 1, Main entry term, French
- déficit immunitaire avec défaut d'expression des molécules HLA
1, record 1, French, d%C3%A9ficit%20immunitaire%20avec%20d%C3%A9faut%20d%27expression%20des%20mol%C3%A9cules%20HLA
masculine noun
Record 1, Abbreviations, French
Record 1, Synonyms, French
Record 1, Textual support, French
Record number: 1, Textual support number: 1 OBS
Déficit immunitaire caractérisé par la présence en nombre normal de toutes les populations lymphocytaires et macrophagiques impliquées dans les réponses immunitaires, mais celles-ci sont devenues incapables d'exercer leurs fonctions du fait d'un défaut d'expression membranaire des produits du complexe majeur d'histocompatibilité (antigènes HLA de classe I et de classe II). 2, record 1, French, - d%C3%A9ficit%20immunitaire%20avec%20d%C3%A9faut%20d%27expression%20des%20mol%C3%A9cules%20HLA
Record 1, Spanish
Record 1, Textual support, Spanish
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