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chimeric monoclonal antibody [1 record]
Record 1 - internal organization data 2014-08-11
Record 1, English
Record 1, Subject field(s)
- Immunology
Record 1, Main entry term, English
- chimeric monoclonal antibody
1, record 1, English, chimeric%20monoclonal%20antibody
correct
Record 1, Abbreviations, English
Record 1, Synonyms, English
- chimeric antibody 2, record 1, English, chimeric%20antibody
correct
Record 1, Textual support, English
Record number: 1, Textual support number: 1 DEF
A recombinant or genetically engineered antibody (e.g. a mouse monoclonal) which contains polypeptides or domains from a different species (e.g. humans) often introduced to reduce the antibody’s immunogenicity. 3, record 1, English, - chimeric%20monoclonal%20antibody
Record number: 1, Textual support number: 1 CONT
A chimeric antibody is one of which both chain types are chimeric as a result of antibody engineering. A chimeric chain is a chain that contains a foreign variable domain (V-D-J-region) (originating from one species other than human, or synthetic) linked to a constant region (C-region) of human origin. 4, record 1, English, - chimeric%20monoclonal%20antibody
Record 1, Key term(s)
- chimaeric antibody
Record 1, French
Record 1, Domaine(s)
- Immunologie
Record 1, Main entry term, French
- anticorps monoclonal chimérique
1, record 1, French, anticorps%20monoclonal%20chim%C3%A9rique
correct, masculine noun
Record 1, Abbreviations, French
Record 1, Synonyms, French
- anticorps chimérique 2, record 1, French, anticorps%20chim%C3%A9rique
correct, masculine noun
- anticorps chimère 3, record 1, French, anticorps%20chim%C3%A8re
correct, masculine noun
Record 1, Textual support, French
Record number: 1, Textual support number: 1 CONT
[...] le développement de l’ingénierie génétique des anticorps [...] a permis de transformer progressivement les anticorps murins en anticorps humains. Cette transformation a d’abord conduit à la construction d’anticorps chimériques, dans lesquels les régions constantes des chaînes lourdes et légères des immunoglobulines murines sont remplacées par des régions constantes humaines [...] Cette chimérisation conduit à une diminution importante des réponses immunes dirigées contre les régions murines [...] 4, record 1, French, - anticorps%20monoclonal%20chim%C3%A9rique
Record 1, Spanish
Record 1, Textual support, Spanish
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