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common acute lymphoblastic leukemia antigen [1 record]

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Record 1 1993-01-26

English

Subject field(s)
  • Immunology
DEF

A tumor-associated antigen occurring on lymphoblasts in about 80 per cent of patients with acute lymphoblastic leukemia (ALL) and also in 40-50 per cent of patients with blastic phase chronic myelogenous leukemia (CML). It does not occur on normal lymphoid cells except during fetal development.

French

Domaine(s)
  • Immunologie
CONT

[...] il semble bien exister des cellules, parfois qualifiées de prépré-B, à haut index mitotique. Source apparemment préférentielle de renouvellement des cellules B, ces cellules porteraient déjà certains antigènes de différenciation de la lignée B comme, chez l'homme, l'antigène B ou certains antigènes perdus dans la suite du développement comme l'antigène CALLA («Common Acute Lymphoblastic Leukemia Antigen»), défini par un anticorps monoclonal produit contre des cellules leucémiques.

Spanish

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