TERMIUM Plus®

The Government of Canada’s terminology and linguistic data bank.

enzyme replacement therapy [1 record]

Record 1 2023-03-30

English

Subject field(s)
  • Pharmacology
  • Non-Surgical Treatment
DEF

Treatment of diseases that are characterized by the absence of a particular enzyme as a result of genetic malfunction or because of tissue malfunction ...

CONT

... enzyme replacement therapy (ERT) has been successfully used in Gaucher disease and ... other lysosomal disorders, including Fabry disease.

OBS

The deficient or absent enzyme is usually administered intravenously.

French

Domaine(s)
  • Pharmacologie
  • Traitements non chirurgicaux
DEF

Thérapeutique utilisant des enzymes recombinantes, notamment dans des déficits héréditaires [...]

CONT

Le traitement enzymatique substitutif [utilisé dans les maladies de surcharge lysosomale] consiste à administrer au patient l'enzyme (recombinante) déficiente dans la pathologie dont il est atteint. Le traitement enzymatique substitutif augmente [...] la concentration de l'enzyme manquante et participe à la dégradation du substrat toxique accumulé dans les cellules de l'organisme. Le traitement [...] ne corrige pas l'anomalie génétique, mais [fournit] l'enzyme déficitaire.

Spanish

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