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excitotoxicity [1 record]

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Record 1 2011-07-14

English

Subject field(s)
  • Toxicology
  • Nervous System
DEF

The pathological process by which neurons are damaged and killed by the overactivations of receptors for the excitatory neurotransmitter glutamate, such as the NMDA [N-methyl D-aspartate] receptor and AMPA [α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid] receptor.

French

Domaine(s)
  • Toxicologie
  • Système nerveux
CONT

Précocement, l'activation anormale de différents types de récepteurs excitateurs neuronaux, tel le récepteur NMDA [N-methyl-D-aspartate], provoque une entrée massive de calcium dans la cellule : c'est le phénomène d'excitotoxicité.

Spanish

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