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The Government of Canada’s terminology and linguistic data bank.
margin-of-safety [1 record]
Record 1 - internal organization data 1991-11-21
Record 1, English
Record 1, Subject field(s)
- Pharmaceutical Manufacturing
Record 1, Main entry term, English
- margin-of-safety
1, record 1, English, margin%2Dof%2Dsafety
correct
Record 1, Abbreviations, English
Record 1, Synonyms, English
- margin of safety 2, record 1, English, margin%20of%20safety
Record 1, Textual support, English
Record number: 1, Textual support number: 1 DEF
before the new drug can be clinically tested for the first time in man ... it must always be tested in the laboratories in several species of animals to establish its pharmacological and toxicological properties. 2, record 1, English, - margin%2Dof%2Dsafety
Record number: 1, Textual support number: 1 CONT
Since the margin of safety between therapeutically effective doses and toxic doses is often narrow, much time and effort are spent in trying to increase this margin, to uncover and study mechanisms of toxicity, and to develop theories concerning interactions of chemicals with the biological system of man. 2, record 1, English, - margin%2Dof%2Dsafety
Record 1, French
Record 1, Domaine(s)
- Fabrication des produits pharmaceutiques
Record 1, Main entry term, French
- marge d'innocuité
1, record 1, French, marge%20d%27innocuit%C3%A9
correct, feminine noun
Record 1, Abbreviations, French
Record 1, Synonyms, French
- marge de sécurité 2, record 1, French, marge%20de%20s%C3%A9curit%C3%A9
feminine noun
Record 1, Textual support, French
Record number: 1, Textual support number: 1 DEF
La "marge d'innocuité" est le rapport entre la dose maximale recommandée et la dose minimale produisant des effets toxiques. 1, record 1, French, - marge%20d%27innocuit%C3%A9
Record number: 1, Textual support number: 1 CONT
La marge de sécurité est établie d'après la limite de l'action toxique qui est déterminée par la constatation des doses mortelles pour les animaux en expérience. 2, record 1, French, - marge%20d%27innocuit%C3%A9
Record number: 1, Textual support number: 2 CONT
On peut ainsi établir une marge de sécurité d'une substance entre les doses thérapeutiques usuelles et les doses maximales tolérées. 2, record 1, French, - marge%20d%27innocuit%C3%A9
Record 1, Spanish
Record 1, Textual support, Spanish
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