TERMIUM Plus®

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nephritic factor [1 record]

Record 1 2006-02-27

English

Subject field(s)
  • Immunology
DEF

An autoantibody found in high concentrations in some kidney diseases which binds to, and stabilizes C3b,Bb, thus potentiating alternative pathway activity.

CONT

Nephritic factor is an immunoglobulin found in patients with partial lipodystrophy and/or mesangiocapillary glomerulonephritis. It binds to the alternative pathway convertase enzyme C3bBd and stabilizes it by inhibiting release of Bb.

French

Domaine(s)
  • Immunologie
DEF

Auto-anticorps dirigé contre la C3-convertase de la voie alterne. Cette spécifique explique sa fonction d'activateur de la voie alterne du complément.

CONT

Certaines protéines peuvent activer la voie alterne : 1) le facteur du venin de cobra [...]; le facteur néphritique, qui est un autoanticorps (IgG) dirigé contre la C3 convertase C3bBb; se fixant à elle, il stabilise le complexe qui résiste à l'action du (facteur) H; 3) la properdine [...]

Spanish

Campo(s) temático(s)
  • Inmunología
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