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déterminant hapténique majeur [1 record]
Record 1 - internal organization data 1993-02-11
Record 1, English
Record 1, Subject field(s)
- Immunology
Record 1, Main entry term, English
- major determinant 1, record 1, English, major%20determinant
Record 1, Abbreviations, English
Record 1, Synonyms, English
Record 1, Textual support, English
Record number: 1, Textual support number: 1 CONT
Penicillin produces immunologic response, as do most drug antigens, in almost all treated patients. However, only a small proportion of patients develop adverse symptoms or signs due to this immunologic reaction. The drug and its metabolites are small molecules and thus are haptens which must bind to protein before they will induce an immunologic response. The major metabolic product is the penicilloyl group, referred to as the major determinant. 1, record 1, English, - major%20determinant
Record 1, French
Record 1, Domaine(s)
- Immunologie
Record 1, Main entry term, French
- déterminant hapténique majeur
1, record 1, French, d%C3%A9terminant%20hapt%C3%A9nique%20majeur
masculine noun
Record 1, Abbreviations, French
Record 1, Synonyms, French
- déterminant majeur 2, record 1, French, d%C3%A9terminant%20majeur
masculine noun
- déterminant immunodominant 2, record 1, French, d%C3%A9terminant%20immunodominant
masculine noun
Record 1, Textual support, French
Record number: 1, Textual support number: 1 CONT
[...] plusieurs produits de dégradation de la pénicilline G donnent lieu à des complexes haptènes-protéines distincts, notamment l'acide benzylpénicillénique, l'acide benzylpénicilloïque (BPO) et l'acide benzylpénamaldique. Chez l'homme, c'est le groupe BPO qui est le déterminant hapténique majeur. 1, record 1, French, - d%C3%A9terminant%20hapt%C3%A9nique%20majeur
Record number: 1, Textual support number: 2 CONT
[...] les déterminants reconnus comme majeurs (ou immunodominants) seraient ceux ayant la plus grande mobilité (ce qui est d'ailleurs le cas des déterminants les plus exposés à la surface de la molécule). (J.-F. Bach, P. Lesavre. Op, cit., p. 42). 2, record 1, French, - d%C3%A9terminant%20hapt%C3%A9nique%20majeur
Record 1, Spanish
Record 1, Textual support, Spanish
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