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2-DESOXYRIBONUCLEOTIDE TRIPHOSPHATE [1 record]

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Record 1 1997-01-20

English

Subject field(s)
  • Genetics
CONT

Here we describe changes in dNTP metabolism that precede DNA fragmentation in a model of apoptosis driven by deprivation of the cytokine interleukin 3 (IL-3). In haemopoietic BAF3 cells, IL-3 withdrawal leads to a rapid decrease in the size of dATP, dTTP and dGTP pools without affecting dCTP levels. This imbalance in dNTP pools precedes DNA fragmentation and is accompanied by down-regulation of enzymes controlling the de novo and salvage pathways of dNTP synthesis, ribonucleotide reductase and thymidine kinase (TK) respectively.

OBS

Biochemical Journal, Biochem. J. (1996) 316, 421 425 (Printed in Great Britain).

French

Domaine(s)
  • Génétique
OBS

Précurseur utilisé pour la synthèse de l'ADN.

Spanish

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