TERMIUM Plus®

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HIGH TOXICITY [22 records]

Record 1 2020-09-01

English

Subject field(s)
  • Toxicology
DEF

[A test] used to identify hazard potential resulting from very short exposures.

CONT

In most acute toxicity tests, each test animal is administered a single(relatively high) dose of the test substance, observed for 1 or 2 weeks for signs of treatment-related effects, then necropsied. Some acute toxicity tests(such as the "classical" LD50 [lethal dose 50] test) are designed to determine the mean lethal dose of the test substance.

CONT

Acute toxicity assay by using microbes as bioindicators is an effective tool for reflecting the impact of water pollution on organisms.

French

Domaine(s)
  • Toxicologie
CONT

Les résultats de l'essai de toxicité aigüe permettent : [d'évaluer de façon quantitative] la dose létale[, de déterminer] la nature des effets toxiques aigus[, de prévoir] les signes cliniques observés en cas de surdosage aigu chez l'homme[, de choisir] les doses à utiliser pour les épreuves de toxicité par administration répétées [et de déterminer] l'index thérapeutique [...]

Spanish

Save record 1

Record 2 2018-05-23

English

Subject field(s)
  • Pollutants
  • Chemistry
  • Occupational Health and Safety
CONT

The following chemical properties are of most concern when preparing for possible chemical spills : flammability, reactivity to air or water, corrosion, and high toxicity.

French

Domaine(s)
  • Agents de pollution
  • Chimie
  • Santé et sécurité au travail

Spanish

Save record 2

Record 3 2016-11-02

English

Subject field(s)
  • Plastics Manufacturing
DEF

A polymer of styrene.

CONT

Polystyrene is made by bulk or suspension polymerization of styrene.... Its major characteristics include rigidity, transparency, high refractive index, no taste, odor, or toxicity, good electrical insulation characteristics, low water absorption, and ease of coloring and processing. It is, however, attacked by hydrocarbons, esters, ketones, and essential oils. A more serious limitation of polystyrene in many applications is its brittleness.

OBS

polystyrene; PS: term, abbreviation and definition standardized by ISO.

French

Domaine(s)
  • Plasturgie
DEF

Polymère du styrène.

CONT

Le polystyrène est obtenu par polymérisation du styrène fabriqué par alkylation du benzène par l'éthylène et déshydrogénation de l'éthylbenzène.

OBS

polystyrène; PS : terme, abréviation et définition normalisés par l'ISO.

Spanish

Campo(s) temático(s)
  • Fabricación de plásticos
DEF

Polímero de estireno.

OBS

Producto de polimerización del estireno. Es una de las materias plásticas más valiosas. Es químicamente resistente y de escaso peso específico. Se emplea como aislante del sonido, de la temperatura y de la corriente eléctrica.

OBS

PS, por sus siglas en inglés.

Save record 3

Record 4 2012-01-30

English

Subject field(s)
  • Chemical Elements and Compounds
  • Agricultural Chemicals
  • Crop Protection
Universal entry(ies)
C20H40N2•C2H4O2
formula, see observation
C17H35C3H5N2•CH3COOH
formula, see observation
556-22-9
CAS number
OBS

glyodin : Generic name for 2-heptadecyl-2-imidazoline acetate [or] 2-heptadecylglyoxalidine acetate. Properties : Light orange crystals insoluble in water. Toxicity probably low; high concentrations are irritating to skin and eyes. Uses : fungicide(fruits).

OBS

2-heptadecyl-4,5-dihydro-1H-imidazole monoacetate: The capital letter "H" must be italicized.

OBS

glyodin: [This] name is not acceptable for use in the United Kingdom, as it is in conflict with a trade mark registered in that country.

OBS

Also known under commercial designations, such as: Crag 341; experimental fungicide 341; glyoxide dry.

OBS

Chemical formula: C20H40N2•C2H4O2 or C17H35C3H5N2•CH3COOH

French

Domaine(s)
  • Éléments et composés chimiques
  • Agents chimiques (Agriculture)
  • Protection des végétaux
Entrée(s) universelle(s)
C20H40N2•C2H4O2
formula, see observation
C17H35C3H5N2•CH3COOH
formula, see observation
556-22-9
CAS number
DEF

Produit chimique de formule C20H40N2•C2H4O2 ou C17H35C3H5N2•CH3COOH se présentant sous la forme de cristaux orange, insoluble dans l'eau, soluble dans l'isopropanol, utilisé comme fongicide.

OBS

monoacétate de 2-heptadécyl-4,5-dihydro-1H-imidazole : La lettre majuscule «H» s'écrit en italique.

Spanish

Save record 4

Record 5 2011-11-09

English

Subject field(s)
  • Toxicology
  • Radiation Protection
DEF

[The] potential of an isotope to cause damage to living tissue by absorption of energy from the disintegration of the radioactive material introduced into the body.

OBS

[Radiotoxicity is] the toxicity attributable to ionizing radiation emitted by an incorporated radionuclide and its daughters; radiotoxicity is related not only to the radioactive characteristics of this radionuclide but also to its chemical and physical state and to metabolism of this element in the body or in the organ.

OBS

According to their relative radiotoxicity, radionuclides are classified into four categories :high toxicity; medium toxicity(sub-group A) ;medium toxicity(sub-group B) ;and low toxicity.

OBS

radiotoxicity: term standardized by ISO in 1997.

Key term(s)
  • radio-toxicity

French

Domaine(s)
  • Toxicologie
  • Radioprotection
DEF

Capacité d'une substance incorporée à entraîner des effets nocifs pour l'organisme du fait de sa radioactivité.

CONT

Compte tenu de leur activité massique faible, l'uranium 238, l'uranium naturel (qui contient 99,3 % en masse d'uranium 238) et l'uranium faiblement enrichi peuvent dans certains cas présenter une toxicité chimique pour le rein (lésions des cellules tubulaires) qui l'emporte sur la radiotoxicité.

CONT

[...] pour l'isotope 237 [du neptunium], qui a une période radioactive de l'ordre de 2 millions d'années, il a été possible de mettre en évidence une toxicité chimique qui, pour les très fortes incorporations, l'emporte sur la toxicité radiologique : la dose pondérale qui entraîne la mort des animaux en deux jours est de l'ordre d'une dizaine de milligrammes par kilogramme de poids corporel [...]

OBS

[Radiotoxicité se dit de la] toxicité liée aux rayonnements émis par un élément radioactif présent dans l'organisme.

OBS

[Le terme radiotoxicité se dit de la] toxicité due aux rayonnements ionisants et plus spécialement aux rayons X.

OBS

Selon leur radioactivité relative, on classe les radionucléides en quatre catégories de risque : très élevée, élevée, moyenne et faible.

OBS

radiotoxicité : terme normalisé par l'ISO en 1997; terme et définition publiés au Journal officiel de la République française le 22 février 2009.

Spanish

Campo(s) temático(s)
  • Toxicología
  • Protección contra la radiación
DEF

Toxicidad ligada a la absorción de materias reactivas en el organismo humano.

OBS

Según su radiactividad relativa se clasifican los radionucleidos en cuatro categorías, a causa del riesgo: radiotoxicidad muy alta, alta, media y débil.

Save record 5

Record 6 2011-04-12

English

Subject field(s)
  • Trade Names
  • Medication
OBS

Paradoxically, because of its toxicity and its high specificity for beta cells, streptozotocin has been used with some success to treat a rare tumor of human beta cells known as insulinoma. In general, however, drugs and chemicals that kill beta cells were employed merely as tools for investigating the pathogenesis of diabetes in experimental animals. Then in 1975 a rodent poison known as Vacor, which has a molecular structure resembling that of streptozotocin, was introduced into the U. S.

OBS

A trademark of Rohm and Haas Co.

Key term(s)
  • Vacor

French

Domaine(s)
  • Appellations commerciales
  • Médicaments
OBS

Paradoxalement, du fait de sa toxicité et de sa haute spécificité d'action au niveau des cellules bêta, on a pu utiliser la streptozotocine avec un certain succès comme traitement d'une tumeur des cellules bêta, (rare chez l'homme), appelée insulinome. En général, cependant, les drogues et les agents chimiques qui tuent les cellules bêta sont uniquement utilisés comme outils de recherche pour étudier la pathogénie du diabète chez les animaux de laboratoire. Ainsi en 1975, un raticide dénommé Vacor, dont la structure moléculaire ressemble à celle de la streptozotocine, a été introduit aux États-Unis.

OBS

VacorMC : Marque de commerce de Rohm and Haas Co.

Spanish

Save record 6

Record 7 2006-08-08

English

Subject field(s)
  • Animal Diseases
  • Poultry Production
CONT

Gizzard erosion is a condition seen in broiler chickens caused by gizzerosine toxicity.

OBS

Gizzerosine is formed by a reaction between the 3 amino group of lysine with free histidine during the heating of fish meal. The amount of heat to which fish meal is exposed during the drying process is critical in the formation of gizzerosine.

OBS

So far gizzerosine toxicity have only been described in chickens, possibly due to the high level of fish meal in the diets of this species... The question of the influence of gizzerosine on horses and other species is however still unanswered.

French

Domaine(s)
  • Maladies des animaux
  • Élevage des volailles
CONT

Une équipe japonaise vient de reproduire expérimentalement une forte érosion du gésier sur des poulets de chair de différents âges, en leur inoculant un Adénovirus aviaire de type I (souche 99ZH).

OBS

Il a été signalé que la gizzérosine provoque l'érosion du gésier (EG) chez les poulets [...]

OBS

érosion : lésion de la peau ou d'une muqueuse avec perte de substance très superficielle.

Spanish

Save record 7

Record 8 2004-04-01

English

Subject field(s)
  • Chemical Elements and Compounds
CONT

The T values that were slightly above the guideline of 1. 0 were due to relatively high concentrations of methylcyclosiloxanes in the samples. These compounds primarily cause injury to the respiratory system(not irritation) and reproductive toxicity.

OBS

methylcyclosiloxane: generic name.

French

Domaine(s)
  • Éléments et composés chimiques
CONT

Siloxanes et silicones, diméthyl, à groupement terminal vinyl, polymères avec les diméthylcyclosiloxanes, méthylphénylcyclosiloxanes et méthylvinylcyclosiloxanes.

OBS

méthylcyclosiloxane : terme générique.

Spanish

Save record 8

Record 9 - external organization data 2004-03-17

English

Subject field(s)
  • General Vocabulary
  • Compartment - Canadian Nuclear Safety Commission
CONT

Ontario has an interim objective of 5 ug/L for chemical toxicity, but the uncertainty factor is high and it's based on a 96h-LC50 to fathead minnow.

French

Domaine(s)
  • Vocabulaire général
  • Tiroir - Commission canadienne de sûreté nucléaire
CONT

L'Ontario a fixé un objectif temporaire de 5 ug/L pour la toxicité chimique, mais le facteur d'incertitude est élevé et est fondé sur une CL50 - 96 h pour la tête-de-boule.

Spanish

Save record 9

Record 10 - external organization data 2004-03-12

English

Subject field(s)
  • General Vocabulary
  • Compartment - Canadian Nuclear Safety Commission
CONT

Ontario has an interim objective of 5 ug/L for chemical toxicity, but the uncertainty factoris high and it's based on a 96h-LC50 to fathead minnow.

French

Domaine(s)
  • Vocabulaire général
  • Tiroir - Commission canadienne de sûreté nucléaire
CONT

L'Ontario a fixé un objectif temporaire de 5 ug/L pour la toxicité chimique, mais le facteur d'incertitude est élevé et est fondé sur une CL50 - 96 h pour la tête-de-boule.

Spanish

Save record 10

Record 11 2004-02-16

English

Subject field(s)
  • Effects of Pollution
  • Toxicology
  • Reproduction (Medicine)
CONT

Reproductive effects are problems in the reproductive process which may be caused by a substance. Possible reproductive effects include reduced fertility in the male or female, menstrual changes, miscarriage, embryotoxicity, fetotoxicity, teratogenicity, or harmful effects to the nursing infant from chemicals in breast milk. Most chemicals can cause reproductive effects if there is an extremely high exposure. In these cases, the exposed person would experience other noticeable signs and symptoms caused by the exposure. These signs and symptoms act as a warning of toxicity. Chemicals which cause reproductive effects in the absence of other significant harmful effects are regarded as true reproductive hazards. Very few workplace chemicals are known to be true reproductive hazards.

CONT

Health Hazard Data: Route of entry. Skin contact. Skin absorption. Eye contact. Effect of acute exposure. Carcinogenecity. Reproductive effects.

French

Domaine(s)
  • Effets de la pollution
  • Toxicologie
  • Reproduction (Médecine)
DEF

Effets d'une substance sur le processus de reproduction.

CONT

Des effets sur le comportement, après exposition en cours de gestation, étudiés dans le chapitre sur le système nerveux central, le plomb possède d'autres effets néfastes sur la reproduction. [...] Effets tératogènes. [...] Effets hypotrophiques. [...] Effets abortifs. [...] Effets sur la fécondité. [...] Effets sur la spermatogénèse. [...] Effets sur l'évolution de la grossesse.

OBS

génésique (adjectif) : Se dit de ce qui a trait à la génération et aux fonctions de la génération.

OBS

génération : Fonction par laquelle les êtres organisés se reproduisent; reproduction (vieilli).

Spanish

Save record 11

Record 12 2004-02-16

English

Subject field(s)
  • Chemical Elements and Compounds
  • Pollutants
CONT

Fluoroalkenes. Even with double-bonded fluorocarbons, we still can have fairly high lethal concentrations and fairly low toxicity. When you get down to this fellow, perfluoroisobutylene, it is extremely toxic. Hexafluoropropylene, which is used as an intermediate in polymer production, is moderately toxic via inhalation.

OBS

fluorinated alkene; fluoroalkene: generic terms.

Key term(s)
  • fluorinated alkenes
  • fluoroalkenes

French

Domaine(s)
  • Éléments et composés chimiques
  • Agents de pollution
DEF

Dérivé fluoré d'un hydrocarbure insaturé acyclique à double liaison carbone.

OBS

alcène fluoré; fluoroalcène : termes génériques.

Key term(s)
  • alcènes fluorés
  • fluoralcènes
  • carbures éthyléniques fluorés

Spanish

Save record 12

Record 13 2001-07-20

English

Subject field(s)
  • Orbital Stations
CONT

The availability of ... resources is not equal at all EFUs [Exposed Facility Units]. For example, higher masses of 2500 kg can be accommodated at two EFU locations, one on the wake and the other on the port side of the EF [JEM - Exposed Facility]. The listed mass values are maximums per site. ... Each site is provided a moderate temperature non-water fluid (fluorinert) loop for heat rejection.

OBS

Fluorinert [belongs to] a family of perfluorinated liquids offering unique properties ideally suited to the demanding requirements of electronics manufacturing, heat transfer and other specialized applications. [It is] non-flammable, non-corrosive, compatible with sensitive materials, [has] low toxicity and high dielectric strength.

OBS

Fluorinert loop: term officially approved by the International Space Station official approval Group (ISSOAG).

French

Domaine(s)
  • Stations orbitales
OBS

Stables thermiquement, inertes chimiquement, [les] liquides électroniques Fluorinert [sont] compatibles avec les composants électroniques les plus sensibles, et, notamment, avec ceux qui doivent être refroidis, soudés ou contrôlés. Incolores, inodores et ininflammables, ils ne laissent pas de résidus [et] ne détruisent pas la couche d'ozone.

OBS

boucle Fluorinert : terme uniformisé par le Groupe de travail de la terminologie de la Station spatiale internationale (GTTSSI).

Spanish

Save record 13

Record 14 2000-10-13

English

Subject field(s)
  • Pharmacy
CONT

With high doses of hydralazine, slow acetylators are more likely to develop antinuclear antibodies and the rhumatoid type of hydralazine toxicity.

French

Domaine(s)
  • Pharmacie
CONT

Après une dose accumulée de 50 g d'hydralazine, 50% des acétylateurs lents ont des facteurs antinucléaires positifs alors qu'une fréquence identique n'est observée qu'après une dose cumulée de 200 g pour les acétylateurs rapides. (Source : Médecine et hygiène, 23 avr. 1986, vol. 44, p. 1168).

Spanish

Campo(s) temático(s)
  • Farmacia
Save record 14

Record 15 1996-04-19

English

Subject field(s)
  • Environmental Studies and Analyses
  • Animal Behaviour
  • Aquaculture
CONT

... high priority was given to predictive research with unique experiments in modelling pollution dispersion and assimilation, simulation of expected effluents, fish behaviour and toxicity bioassays with simulated effluent.

French

Domaine(s)
  • Études et analyses environnementales
  • Comportement animal
  • Aquaculture

Spanish

Save record 15

Record 16 1992-11-27

English

Subject field(s)
  • Toxicology
  • Nuclear Power Stations
CONT

People are often confused; they correctly attribute to high-level nuclear waste a high specific toxicity(toxicity per unit weight), but forget that there is a much smaller quantity, which means that nuclear waste is the only waste in society for which we have a reasonable solution.

French

Domaine(s)
  • Toxicologie
  • Centrales nucléaires

Spanish

Save record 16

Record 17 1989-03-31

English

Subject field(s)
  • Environmental Studies and Analyses
CONT

... high priority was given to predictive research with unique experiments in modelling pollution dispersion and assimilation, simulation of expected effluents, fish behaviour and toxicity bioassays with simulated effluent.

French

Domaine(s)
  • Études et analyses environnementales
OBS

l'expression «dispersion des polluants» serait plus logique.

Spanish

Save record 17

Record 18 1988-06-25

English

Subject field(s)
  • Biochemistry
OBS

Determination of glucose level.

OBS

Comparative studies are reported on the reliability of the results in the determination of blood glucose by glucosooxidase-peroxidase and o-tuluidine methods. Both methods have a good correlation, r=0, 9575 with n=61. The results indicate that the GOD/POD method and o-toluidine method have a good reproducibility in time and series and high accuracy. Due to the poorer toxicity of GOD/POD-method its broader implementation in routine practice is recommended.

OBS

Excerpted from the MEDLINE data base.

French

Domaine(s)
  • Biochimie

Spanish

Save record 18

Record 19 1988-01-21

English

Subject field(s)
  • Environmental Studies and Analyses
CONT

... high priority was given to predictive research with unique experiments in modelling pollution dispersion and assimilation, simulation of expected effluents, fish behaviour and toxicity bioassays with simulated effluent

French

Domaine(s)
  • Études et analyses environnementales

Spanish

Save record 19

Record 20 1988-01-20

English

Subject field(s)
  • Environmental Studies and Analyses
CONT

... high priority was given to predictive research with unique experiments in modelling pollution dispersion and assimilation, simulation of expected effluents, fish behaviour and toxicity bioassays with simulated effluent.

French

Domaine(s)
  • Études et analyses environnementales

Spanish

Save record 20

Record 21 1988-01-20

English

Subject field(s)
  • Environmental Studies and Analyses
CONT

... high priority was given to predictive research with unique experiments in modelling pollution dispersion and assimilation, simulation of expected effluents, fish behaviour and toxicity bioassays with simulated effluent.

French

Domaine(s)
  • Études et analyses environnementales

Spanish

Save record 21

Record 22 1988-01-20

English

Subject field(s)
  • Environmental Studies and Analyses
CONT

... high priority was given to predictive research with unique experiments in modelling pollution dispersion and assimilation, simulation of expected effluents, fish behaviour and toxicity bioassays with simulated effluent.

French

Domaine(s)
  • Études et analyses environnementales

Spanish

Save record 22

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