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ANTI-INTERFERON [1 record]
Record 1 - internal organization data 1998-05-26
Record 1, English
Record 1, Subject field(s)
- Genetics
Record 1, Main entry term, English
- anti-interferon
1, record 1, English, anti%2Dinterferon
correct
Record 1, Abbreviations, English
Record 1, Synonyms, English
Record 1, Textual support, English
Record number: 1, Textual support number: 1 CONT
Alpha and beta interferons play an important role in the regulation of the normal immune response. The abnormal production of type I interferons can, however, lead to an inappropriate immune response and to the development of autoimmunity and to the rejection of allografts. The cloning of the type I interferon receptor in our laboratory has enabled us to synthesise soluble variants of the receptor and to isolate a monoclonal antibody capable of inhibiting the biologic action of all the type I interferons tested. We have shown that treatment of monkeys with the anti-interferon receptor antibody together with a subeffective dose of cyclosporin A results in permanent survival of skin and bone marrow allografts. 1, record 1, English, - anti%2Dinterferon
Record 1, French
Record 1, Domaine(s)
- Génétique
Record 1, Main entry term, French
- anti-interféron
1, record 1, French, anti%2Dinterf%C3%A9ron
correct, masculine noun
Record 1, Abbreviations, French
Record 1, Synonyms, French
Record 1, Textual support, French
Record number: 1, Textual support number: 1 CONT
Les immunomodulateurs agissent soit en bloquant les lymphocytes qui franchissent la barrière sang-cerveau (le copolymère, bien toléré, mais qui n'est pas encore autorisé en Europe) soit en s'opposant à l'action de certaines molécules destructives de la myéline (l'interféron ß). Ils réduisent la fréquence des poussées d'environ 30%; l'interféron ß semble, en outre, retarder l'apparition du handicap. En revanche, ce dernier présente des effets secondaires (fatigue, maux de tête, fièvre), qui disparaissent toutefois au bout de quelques semaines. Autre inconvénient, environ 20% des patients développent des anticorps anti-interféron ß. 2, record 1, French, - anti%2Dinterf%C3%A9ron
Record 1, Spanish
Record 1, Textual support, Spanish
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