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CATALYTIC ANTIBODY [1 record]
Record 1 - internal organization data 2013-08-27
Record 1, English
Record 1, Subject field(s)
- Biological Sciences
Record 1, Main entry term, English
- abzyme
1, record 1, English, abzyme
correct
Record 1, Abbreviations, English
Record 1, Synonyms, English
- catalytic enzyme 2, record 1, English, catalytic%20enzyme
correct
- catalytic antibody 3, record 1, English, catalytic%20antibody
correct
- antibody catalyst 3, record 1, English, antibody%20catalyst
correct
- absyme 3, record 1, English, absyme
correct
Record 1, Textual support, English
Record number: 1, Textual support number: 1 DEF
An antibody prepared to a haptenic group which resembles the transition state of a given reaction. 4, record 1, English, - abzyme
Record number: 1, Textual support number: 1 CONT
The combining sites of such antibodies should be complementary to the transition state and should cause an acceleration by forcing bound substrate to resemble transition state. These antibodies have catalytic activity. 4, record 1, English, - abzyme
Record number: 1, Textual support number: 2 CONT
The future of abzymes is not assured. Manufacture of the transition-state molecules (the high-energy intermediate forms) is a formidable feat of organic chemistry, which may be useless because nobody knows what the states really are. Guesswork may prove wrong. When a mouse makes antibodies to the hardwon transition-state molecule, the antibody may react with the wrong bit of the molecule and fail to stabilise it. 5, record 1, English, - abzyme
Record 1, French
Record 1, Domaine(s)
- Sciences biologiques
Record 1, Main entry term, French
- abzyme
1, record 1, French, abzyme
correct, masculine noun
Record 1, Abbreviations, French
Record 1, Synonyms, French
- AC-zyme 2, record 1, French, AC%2Dzyme
correct, masculine noun
- anticorps catalytique 2, record 1, French, anticorps%20catalytique
correct, masculine noun
Record 1, Textual support, French
Record number: 1, Textual support number: 1 DEF
Anticorps reconnaissant spécifiquement des «états de transition [...]»; par exemple, si une réaction s'écrit : A A/B B, A et B étant les produits extrêmes de la réaction et A/B un état de transition réactif et instable, un anticorps spécifiquement dirigé contre l'espèce A/B la stabilisera et augmentera la vitesse de la réaction. 1, record 1, French, - abzyme
Record number: 1, Textual support number: 1 CONT
Les utilisations possibles [...] des anticorps catalytiques semblent être immenses aussi bien dans le domaine de la recherche fondamentale que dans celui des applications en chimie et en médecine. [...] On pourrait ainsi envisager de «fabriquer» des «AC-zymes» spécifiques de toutes les séquences peptidiques désirées, équivalentes, pour les protéines, des enzymes de restriction pour l'ADN. 3, record 1, French, - abzyme
Record 1, Spanish
Record 1, Campo(s) temático(s)
- Ciencias biológicas
Record 1, Main entry term, Spanish
- aczima
1, record 1, Spanish, aczima
correct, feminine noun
Record 1, Abbreviations, Spanish
Record 1, Synonyms, Spanish
- anticuerpo catalítico 1, record 1, Spanish, anticuerpo%20catal%C3%ADtico
correct, masculine noun
Record 1, Textual support, Spanish
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