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CLASSICAL SPORADIC CREUTZFELDT-JAKOB DISEASE [1 record]

Record 1 2011-05-09

English

Subject field(s)
  • Epidemiology
DEF

A subtype of Creutzfeldt-Jakob clinically characterized by a rapidly progressive dementia, behavioural changes with progression to neurological abnormalities and onset of a progressive cerebellar syndrome, and anatomically by microvacuolar spongiform changes in the cerebellar molecular layer accompanied by reactive gliosis and neuronal loss.

OBS

It arises spontaneously in individuals aged between 50 and 75 without any apparent cause.

French

Domaine(s)
  • Épidémiologie
DEF

Forme de la maladie de Creutzfeldt-Jakob caractérisée cliniquement par une détérioration mentale progressive, des troubles comportementaux neurologiques avec une nette prédominance cérébelleuse et, anatomiquement, par une microspongiose au niveau de la couche cellulaire, une réaction gliale avec astrocytose ainsi qu'une déperdition neuronale.

OBS

La cause de cette maladie, qui se déclare en moyenne vers l'âge de 60 ans et atteint les individus isolément, n'a pas encore été trouvée.

Spanish

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