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COMPARATIVE GENOMIC HYBRIDIZATION [1 record]

Record 1 1997-08-29

English

Subject field(s)
  • Genetics
CONT

Breast cancer progression is determined by a complex pattern of multiple genetic aberrations the association of which with patient prognosis is unknown. In this study, we have undertaken a genome-wide screening to detect genetic changes associated with clinical outcome in node-negative breast cancer. Comparative genomic hybridization was used to screen for DNA sequence gains and losses across all human chromosomes in 23 tumors ...

French

Domaine(s)
  • Génétique
CONT

La séquence FISH (hybridation en fluorescence in situ) et le développement des techniques fondées sur son principe sont en train de modifier radicalement les méthodes d'analyse de la génétique. Parmi celles-ci, l'hybridation génomique comparative (CGH) constitue un outil performant d'exploration du génome.

CONT

La CGH est une méthode permettant d'évaluer une modification du nombre de copies d'ADN dans un génome pathologique [...] Son principe est fondé sur la compétition, lors de l'hybridation, entre un ADN génomique normal et un ADN génomique pathologique.

Spanish

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