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GERM-LINE MODIFICATION [1 record]
Record 1 - internal organization data 2008-10-28
Record 1, English
Record 1, Subject field(s)
- Genetics
- Cytology
Record 1, Main entry term, English
- germ-line modification
1, record 1, English, germ%2Dline%20modification
correct
Record 1, Abbreviations, English
Record 1, Synonyms, English
- germ-line alteration 2, record 1, English, germ%2Dline%20alteration
correct
Record 1, Textual support, English
Record number: 1, Textual support number: 1 CONT
Germ-line alteration involves a specific attempt to introduce genetic changes into the germ (reproductive) cells of an individual, with the aim of changing the set of genes passed on to the individual's offspring. 3, record 1, English, - germ%2Dline%20modification
Record 1, Key term(s)
- germline alteration
- germline modification
Record 1, French
Record 1, Domaine(s)
- Génétique
- Cytologie
Record 1, Main entry term, French
- modification des cellules germinales
1, record 1, French, modification%20des%20cellules%20germinales
correct, feminine noun
Record 1, Abbreviations, French
Record 1, Synonyms, French
Record 1, Textual support, French
Record number: 1, Textual support number: 1 CONT
La thérapie génique est sans aucun doute un espoir immense pour les malades, mais [le] terme lui-même est extrêmement ambigu et recouvre des approches très différentes comme la thérapie cellulaire, l'immunisation par ADN, la régulation de l'expression génique, la modification des cellules germinales. 2, record 1, French, - modification%20des%20cellules%20germinales
Record 1, Spanish
Record 1, Campo(s) temático(s)
- Genética
- Citología
Record 1, Main entry term, Spanish
- modificación de células germinales
1, record 1, Spanish, modificaci%C3%B3n%20de%20c%C3%A9lulas%20germinales
correct, feminine noun
Record 1, Abbreviations, Spanish
Record 1, Synonyms, Spanish
- alteración de células germinales 2, record 1, Spanish, alteraci%C3%B3n%20de%20c%C3%A9lulas%20germinales
correct, feminine noun
- modificación génica germinal 3, record 1, Spanish, modificaci%C3%B3n%20g%C3%A9nica%20germinal
correct, feminine noun
Record 1, Textual support, Spanish
Record number: 1, Textual support number: 1 DEF
Técnica de terapia génica que consiste en modificar los espermatozoides u óvulos de un ser vivo, con el objetivo de crear un cambio permanente en el mismo y en los genes transmitidos a sus descendientes. 4, record 1, Spanish, - modificaci%C3%B3n%20de%20c%C3%A9lulas%20germinales
Record number: 1, Textual support number: 1 CONT
La terapia génica se divide en dos categorías. La primera es la alteración de las células germinales, es decir espermatozoides u óvulos,lo que origina un cambio permanente de todo el organismo y generaciones posteriores. Esta terapia génica de la línea germinal no se considera en los seres humanos por razones éticas. 2, record 1, Spanish, - modificaci%C3%B3n%20de%20c%C3%A9lulas%20germinales
Record number: 1, Textual support number: 2 CONT
La modificación génica germinal se caracteriza por la manipulación del Genoma Humano para obtener una alteración del mismo que sea duradera y transmisible hereditariamente, toda vez que se realiza sobre células sexuales o germinales. Supone, en definitiva, la creación de seres humanos transgénicos, respecto de los cuales la modificación genética es hereditaria y pasa a las sucesivas generaciones. 5, record 1, Spanish, - modificaci%C3%B3n%20de%20c%C3%A9lulas%20germinales
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