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GUTLESS VECTOR [1 record]

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Record 1 2010-02-23

English

Subject field(s)
  • Genetics
CONT

The only viral sequences included in the gutless vector are those needed in cis for its replication and packaging. We found that a loxP site next to the packaging site of the gutless virus was necessary to neutralize homologous recombination between ... and the gutless viruses within their packaging domains.

French

Domaine(s)
  • Génétique
CONT

Une des stratégies proposées pour y pallier est de concevoir des vecteurs n'exprimant plus de gènes viraux (gutless vector). Ces constructions, testées chez l'animal, donnent des résultats contradictoires et mettent en évidence que l'immunogénécité, la stabilité de l'expression génique et la persistance in vivo des «gutless vectors» varient en fonction de plusieurs facteurs : origine exacte du vecteur, nature du tissu cible et nature du gène thérapeutique inséré.

Spanish

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