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HELIX-LOOP-HELIX MOTIF [1 record]

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Record 1 1991-07-17

English

Subject field(s)
  • Biochemistry
  • Molecular Biology
DEF

We isolated full-length cDNAs encoding the 43-kD form of human upstream stimulatory factor (USF), a cellular factor required for efficient transcription of the adenovirus major late (AdML) promoter in vitro. Sequence analysis showed USF to be a member of the c-myc-related family of DNA-binding proteins. Using proteins translated in vitro, we identified a DNA-binding domain near the carboxyl terminus, which includes both a helix-loop-helix motif and a leucine repeat.

OBS

Tiré du périodique Américain: Genes & development, 1990, 4 (10), 1730-1740.

French

Domaine(s)
  • Biochimie
  • Biologie moléculaire
CONT

Il existe une grande famille de protéines se liant à l'ADN, exerçant une activité d'inducteurs de différenciation et de modulateurs de transcription, caractérisée par la présence d'un motif protéique dit "hélice-boucle-hélice" localisé à proximité d'une région basique. Le motif hélice-boucle-hélice (HLH, helix-loop-helix) assure la dimérisation de ces protéines, qui se lient sous la forme de dimères à l'ADN par leurs régions basiques.

Key term(s)
  • HLH

Spanish

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