TERMIUM Plus®

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HPRT [2 records]

Filter results by subject field Alphabetical list of terms

Filter results by subject field

Alphabetical list of terms

Record 1 2013-07-11

English

Subject field(s)
  • Biochemistry
DEF

An enzyme of the transferase class that catalyzes the phosphorylation of hypoxanthine or guanine to its corresponding nucleoside monophosphate, a salvage mechanism for recovery of preformed purines, especially in the central nervous system.

French

Domaine(s)
  • Biochimie
DEF

Enzyme catalysant le transfert du radical phosphoribosyle du phosphoribosyl-pyrophosphate sur l'hypoxanthine ou sur la guanine, qu'il transforme respectivement en acide inosinique ou guanylique.

OBS

Cet enzyme joue un rôle important dans le métabolisme des bases puriques dans le foie en permettant la récupération de ces bases libérées lors de la dégradation des nucléotides et d'éviter leur transformation en acide urique.

Spanish

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Record 2 1991-09-12

English

Subject field(s)
  • Biochemistry
  • Biophysics
DEF

An enzyme of the transferase class that catalyzes the reaction hypoxanthine (of guanine) + 5 - phospho - alpha - Delta - ribose I - disphosphate = inosine 5' - monophosphate (or guanasine 5' - monoiphosphate) + pyrophosphate.

French

Domaine(s)
  • Biochimie
  • Biophysique
CONT

Une modification directe du gène Hprt (hypoxanthine phosphoribosyltransférase), pour lequel il est possible de sélectionner les cellules possédant cette fonction (avec le milieu HAT : hypoxanthine-aminoptérine-thymidine) ou au contraire les cellules qui l'ont perdue (avec la 6-TG : 6-thioguanine) peut aussi être obtenue.

Spanish

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