TERMIUM Plus®
The Government of Canada’s terminology and linguistic data bank.
KNOCK-OUT TECHNOLOGY [1 record]
Record 1 - internal organization data 2021-02-25
Record 1, English
Record 1, Subject field(s)
- Biotechnology
- Genetics
Record 1, Main entry term, English
- gene knockout technology
1, record 1, English, gene%20knockout%20technology
correct
Record 1, Abbreviations, English
Record 1, Synonyms, English
- knockout technology 2, record 1, English, knockout%20technology
correct
- knockout technique 3, record 1, English, knockout%20technique
correct
- gene knockout 4, record 1, English, gene%20knockout
correct
- gene disruption 5, record 1, English, gene%20disruption
correct
Record 1, Textual support, English
Record number: 1, Textual support number: 1 DEF
The replacement of a normal gene with a mutated form of the gene by using homologous recombination. 6, record 1, English, - gene%20knockout%20technology
Record number: 1, Textual support number: 1 CONT
We use proprietary gene knockout technology to systematically discover the physiological functions of genes in mice and to identify which corresponding human genes encode potential targets for therapeutic intervention, or drug targets. 1, record 1, English, - gene%20knockout%20technology
Record 1, Key term(s)
- gene knock-out technology
- knock-out technology
- knock-out technique
- gene knock-out
Record 1, French
Record 1, Domaine(s)
- Biotechnologie
- Génétique
Record 1, Main entry term, French
- méthode d'inactivation de gène
1, record 1, French, m%C3%A9thode%20d%27inactivation%20de%20g%C3%A8ne
correct, feminine noun
Record 1, Abbreviations, French
Record 1, Synonyms, French
- technique d'inactivation de gène 2, record 1, French, technique%20d%27inactivation%20de%20g%C3%A8ne
correct, feminine noun
- invalidation génique 3, record 1, French, invalidation%20g%C3%A9nique
correct, feminine noun
- méthode knockout 1, record 1, French, m%C3%A9thode%20knockout
see observation, feminine noun
- technique knockout 4, record 1, French, technique%20knockout
see observation, feminine noun
Record 1, Textual support, French
Record number: 1, Textual support number: 1 DEF
Méthode expérimentale de recherche du rôle d'un gène par l'observation des effets de son inactivation. 3, record 1, French, - m%C3%A9thode%20d%27inactivation%20de%20g%C3%A8ne
Record number: 1, Textual support number: 1 OBS
Le gène considéré est muté par recombinaison homologue dans des cellules souches embryonnaires de souris. Ces cellules au génome modifié sont alors réinjectées dans un embryon de souris aux premiers stades de développement. Elles s'intègrent à l'embryon et participent à la composition des différents tissus. La fonction du gène rendu inactif peut être alors étudiée tout au long du développement de l'animal. 3, record 1, French, - m%C3%A9thode%20d%27inactivation%20de%20g%C3%A8ne
Record number: 1, Textual support number: 2 OBS
technique knockout; méthode knockout : Bien que ces termes soient largement utilisés en français, on recommande de remplacer «knockout» par «inactivation de gène». 5, record 1, French, - m%C3%A9thode%20d%27inactivation%20de%20g%C3%A8ne
Record 1, Key term(s)
- méthode knock-out
- technique knock-out
Record 1, Spanish
Record 1, Campo(s) temático(s)
- Biotecnología
- Genética
Record 1, Main entry term, Spanish
- gen desactivado
1, record 1, Spanish, gen%20desactivado
correct, masculine noun
Record 1, Abbreviations, Spanish
Record 1, Synonyms, Spanish
- gen anulado 1, record 1, Spanish, gen%20anulado
correct, masculine noun
- desactivación génica 2, record 1, Spanish, desactivaci%C3%B3n%20g%C3%A9nica
correct, feminine noun
- técnica de desactivación génica 3, record 1, Spanish, t%C3%A9cnica%20de%20desactivaci%C3%B3n%20g%C3%A9nica
feminine noun
- gen noqueado 1, record 1, Spanish, gen%20noqueado
avoid, see observation, masculine noun
- noqueado génico 4, record 1, Spanish, noqueado%20g%C3%A9nico
avoid, see observation, masculine noun
Record 1, Textual support, Spanish
Record number: 1, Textual support number: 1 DEF
Inactivación de un gen mediante una mutación espontánea o por la integración de un fragmento de DNA modificado especialmente. 4, record 1, Spanish, - gen%20desactivado
Record number: 1, Textual support number: 1 OBS
El término gen noqueado, del término inglés "knock-out gene", hace referencia al proceso de anulación de la expresión de un gen específico en un animal con el fin de estudiar las consecuencias a que da lugar la falta de la proteína correspondiente a ese gen. [...] Referirnos a esta técnica como del 'gen noqueado', traducción literal de la expresión inglesa, no es adecuado en español. Noquear, que curiosamente es una castellanización del término inglés knock out, es un término perteneciente al ámbito popular y pugilístico y que significa vencer a un adversario haciéndole perder el conocimiento; noquear tiene además un sentido de transitoriedad (la pérdida de conocimiento es temporal), lo que podría inducir la falsa idea de que los genes anulados lo son sólo transitoriamente. Cuando queramos referirnos a ratones manipulados mediante esta técnica es mejor escribir "ratones con un gen desactivado", "ratones con un gen no funcional", "ratones con un gen anulado", "ratón con los dos alelos silenciados", etcétera. 1, record 1, Spanish, - gen%20desactivado
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