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LOSS HETEROZYGOSITY [1 record]

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Record 1 2005-03-04

English

Subject field(s)
  • Genetics
CONT

Group phase III clinical trials were assayed for loss of heterozygosity (LOH) with 13 microsatellite polymorphic markers spanning chromosome band 1p36.

Key term(s)
  • heterozygosity loss

French

Domaine(s)
  • Génétique
CONT

Les études génotypiques montrent l'implication d'une perte d'hétérozygotie sur le chromosome 5, conjointe à la mutation du gène APC dans plus de 60 % des adénocarcinomes développés sur adénomes polypoïdes dès le stade de début, tandis que les recherches concernant les adénocarcinomes de type «plan» restent fragmentaires.

Spanish

Campo(s) temático(s)
  • Genética
CONT

Existe pérdida de la heterocigosidad cuando se observa la desaparición de uno de estos alelos en la lesión preneoplásica o neoplásica en comparación con la mucosa normal o el control normal adyacente.

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