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NUCLEOSIDE ANALOG [1 record]
Record 1 - internal organization data 2010-11-23
Record 1, English
Record 1, Subject field(s)
- Medication
Record 1, Main entry term, English
- nucleoside analogue
1, record 1, English, nucleoside%20analogue
correct
Record 1, Abbreviations, English
Record 1, Synonyms, English
- nucleoside analog 2, record 1, English, nucleoside%20analog
correct
Record 1, Textual support, English
Record number: 1, Textual support number: 1 DEF
A chemically related group of drugs used to inhibit HIV. Examples include the first drugs approved to treat HIV infection: AZT, ddI, ddC. They all work by the same mechanism, by inhibiting an enzyme called reverse transcriptase that is critical for HIV's survival. 2, record 1, English, - nucleoside%20analogue
Record 1, French
Record 1, Domaine(s)
- Médicaments
Record 1, Main entry term, French
- analogue de nucléoside
1, record 1, French, analogue%20de%20nucl%C3%A9oside
correct, masculine noun
Record 1, Abbreviations, French
Record 1, Synonyms, French
- analogue nucléosidique 2, record 1, French, analogue%20nucl%C3%A9osidique
correct, masculine noun
Record 1, Textual support, French
Record number: 1, Textual support number: 1 DEF
Médicaments de la première famille historique des antirétroviraux, les inhibiteurs de la reverse-transcriptase (AZT, ddC, ddI, d4T, 3TC) à ce jour. 2, record 1, French, - analogue%20de%20nucl%C3%A9oside
Record 1, Spanish
Record 1, Campo(s) temático(s)
- Medicamentos
Record 1, Main entry term, Spanish
- nucleósido análogo
1, record 1, Spanish, nucle%C3%B3sido%20an%C3%A1logo
masculine noun
Record 1, Abbreviations, Spanish
Record 1, Synonyms, Spanish
Record 1, Textual support, Spanish
Record number: 1, Textual support number: 1 DEF
Compuesto sintético, que carece del grupo fosfatado que tienen los nucleótidos, que actúa como una versión defectuosa del nucleósido natural al inhibir la transcriptasa inversa, la cual es la enzima viral encargada de integrar estas cadenas transcribiendo el código ARN viral al ADN. 1, record 1, Spanish, - nucle%C3%B3sido%20an%C3%A1logo
Record number: 1, Textual support number: 1 OBS
El VIH utiliza al nucleósido para integrarlo a la cadena de ADN de la célula cuando trata de reproducirse. Al ser sustituido el nucleósido natural por el nucleósido análogo, la cadena no puede sintetizarse eficazmente y la replicación no se efectúa. Son nucleósidos análogos el AZT, ddI, ddC, d4T y 3TC. 1, record 1, Spanish, - nucle%C3%B3sido%20an%C3%A1logo
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