TERMIUM Plus^®

Record 1,  Textual support,  English

Record number: 1, Textual support number: 1 CONT

An analysis of the amino acid sequences of variable regions of human and mouse antibody molecules was performed. It involved comparison of their constituent tetrapeptides with those found in a reference set (the somatic self) built with non-immunological proteins found in a protein data base. It appeared that hypervariable regions, particularly CDR1 and CDR3, are often made up of rare tetrapeptides not present in the reference set. As assessed by simple statistical tests, this bias was significant. We discuss its possible connection with the problem of antibody immunogenicity. This result provides indirect support for the existence of idiopeptides predicted by the "peptidic self model".  2, record 1, English, - peptidic%20self%20model

Record 1,  Textual support,  French

Record number: 1, Textual support number: 1 CONT

[...] la tolérance d'un hôte à ses propres protéines (le soi) s'exerce au niveau peptidique, par la délétion fonctionnelle des lymphocytes T capables d'en reconnaître les peptides constitutifs : c'est le modèle du «soi peptidique». En premier lieu, ce modèle permet de donner son véritable sens à la présence de molécules du CMH de classe I à la surface de toutes les cellules.  1, record 1, French, - mod%C3%A8le%20du%20soi%20peptidique

Record 1,  Textual support,  Spanish