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POLYPHOSPHOINOSITIDE [1 record]

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Record 1 2012-01-16

English

Subject field(s)
  • Cytology
CONT

Lipid molecules called polyphosphoinositides, which are found in the cell membrane, can remove gelsolin from actin filaments and allow them to elongate.

OBS

Class of phospholipid molecules [which] is a common constituent of cell membranes and has been implicated in signal transduction within cells ... Lindberg had noticed that polyphosphoinositides could decrease the affinity of profilin, an actin subunit-binding protein [he] discovered in 1977, for actin subunits ... polyphosphoinositides inhibit the actin-binding activity of nearly all proteins that cap and sever actin filaments.

PHR

To synthesize, break down polyphosphoinositide.

PHR

Polyphosphoinositide degradation. Polyphosphoinositides uncap filaments. Synthesis of polyphosphoinositide.

French

Domaine(s)
  • Cytologie
CONT

Les polyphospho-inositides sont des phospholipides, c'est-à-dire des molécules composées d'une partie lipidique et d'une tête phosphatée [...] Lindberg avaient observé que les polyphospho-inositides réduisaient l'affinité de la profiline (une des protéines qui se lient à l'actine) pour les sous-unités d'actine [...] les polyphospho-inositides inhibent la fixation de la plupart des protéines qui s'associent à l'actine et qui agissent comme la gelsoline.

PHR

Les polyphospho-inositides décoiffent les filaments.

PHR

Dégradation des polyphospho-inositides. Synthèse de polyphospho-inositides.

Key term(s)
  • polyphosphoinositide

Spanish

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