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PRESYSTEMIC METABOLISM [1 record]

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Record 1 1988-04-20

English

Subject field(s)
  • Pharmacodynamics
CONT

A particularly important characteristic of drugs that show a high hepatic extraction ratio ... is that on oral administration, presystemic metabolism is significant and the amount of drug reaching the systemic circulation may be considerably less than the dose administered.

French

Domaine(s)
  • Pharmacodynamie
DEF

Transformation subie par les médicaments au niveau du foie avant d'atteindre la circulation systémique.

CONT

Le foie est l'organe de biotransformation le plus important et contribue à la biotransformation hépatique présystémique plus ou moins importante des médicaments administrés par la voie orale.

Spanish

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