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PROTEASE-SENSITIVE PRION PROTEIN [1 record]
Record 1 - internal organization data 1999-06-16
Record 1, English
Record 1, Subject field(s)
- Biochemistry
Record 1, Main entry term, English
- protease-sensitive prion protein
1, record 1, English, protease%2Dsensitive%20prion%20protein
correct
Record 1, Abbreviations, English
- PrPsen 1, record 1, English, PrPsen
correct
Record 1, Synonyms, English
Record 1, Textual support, English
Record number: 1, Textual support number: 1 CONT
The transmissible spongiform encephalopathies are characterized by the conversion of the protease-sensitive prion protein (PrPsen) into a protease-resistant isoform (PrPres) associated with the neuropathogenic process in vivo. Recently, PrPres has been shown to be capable of directly inducing the conversion of PrPsen to PrPres in a cell-free in vitro system. In the present experiments, various PrP peptides were studied for their ability to enhance or inhibit this cell-free conversion reaction. None of the synthetic peptides was able to confer protease-resistance to the labeled PrPsen molecules on their own. 1, record 1, English, - protease%2Dsensitive%20prion%20protein
Record 1, French
Record 1, Domaine(s)
- Biochimie
Record 1, Main entry term, French
- PrP sensible aux protéases
1, record 1, French, PrP%20sensible%20aux%20prot%C3%A9ases
correct, feminine noun
Record 1, Abbreviations, French
- PrPsen 2, record 1, French, PrPsen
correct
Record 1, Synonyms, French
- protéine du prion sensible aux protéases 1, record 1, French, prot%C3%A9ine%20du%20prion%20sensible%20aux%20prot%C3%A9ases
correct, feminine noun
Record 1, Textual support, French
Record number: 1, Textual support number: 1 CONT
Rappelons brièvement les connaissances acquises sur ces deux isoformes de la PrP (protéine du prion). On l'a vu, la protéine normale présente chez l'individu sain est facilement dégradée par les protéases. Elle a été appelée PrPc (pour cellulaire) ou PrPsen (pour sensible aux protéases), afin de distinguer la forme anormale appelée PrPsc dans de la cas de la tremblante (sc pour scrapie) ou PrPes pour résistante. 1, record 1, French, - PrP%20sensible%20aux%20prot%C3%A9ases
Record number: 1, Textual support number: 1 OBS
Protéine du prion présente chez l'individu sain. 3, record 1, French, - PrP%20sensible%20aux%20prot%C3%A9ases
Record 1, Spanish
Record 1, Textual support, Spanish
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