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PROTON IONOPHORE [1 record]

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Record 1 1980-09-01

English

Subject field(s)
  • Biochemistry
OBS

The proton ionophores where first studied as molecules classified functionally as "uncouplers": they inhibit phosphorylation but stimulate respiration. That mode of action is explained by their ability to dissipate a proton gradient. The proton ionophores are all weak acids that readily gain or lose a proton (...) and can diffuse across the [mitochondrial] membrane in either state.

French

Domaine(s)
  • Biochimie
OBS

Les ionophores à protons furent d'abord étudiés en tant qu'agents de découpage: ils inhibent la phosphorylation mais activent la respiration. Ce mode d'action s'explique par leur capacité à abolir un gradient de protons. Les ionophores à protons sont tous des acides faibles qui perdent ou captent facilement un proton (...) et peuvent diffuser à travers la membrane [mitochondriale] sous l'une des deux formes.

Spanish

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