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RNA REPLICASE [1 record]

Record 1 1999-01-27

English

Subject field(s)
  • Genetics
CONT

Nodavirus RNA Replication. We have constructed DNA plasmids and vaccinia virus recombinants that express the RNA replicase of a nodavirus. In the cytoplasm of transfected or infected mammalian cells, this enzyme selectively amplifies its own mRNA by RNA replication. The replicase can also amplify other RNAs if they contain appropriate cis-acting replication signals, and we are striving to harness this ability for vector, vaccine, and gene therapy application.

French

Domaine(s)
  • Génétique
DEF

Enzyme qui, chez les Virus à ARN, catalyse la reproduction (réplication) de cette molécule. Comme l'ARN viral est monocaténaire, la réplication nécessiterait un intermédiaire bicaténaire à partir duquel s'effectuerait la reproduction du brin.

Spanish

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