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SEMI-SYNTHETIC PENICILLIN [1 record]

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Record 1 2008-10-22

English

Subject field(s)
  • Medication
DEF

An antibiotic produced from penicillin by making some chemical changes to its structure.

CONT

Appropriate chemical treatment of a biological precursor to penicillin, isolated from bacterial cultures, resulted in the formation of a number of so-called semi-synthetic penicillins. The most important of these are Methicillin and Ampicillin.

French

Domaine(s)
  • Médicaments
CONT

La méthicilline, une pénicilline semi-synthétique a été développée pour remplacer la pénicilline, mais au début des années 60 les premières souches résistantes à la méthicilline apparaissent.

CONT

En janvier 1958, l'extraction du 6-APA étant réalisée, la production des pénicillines semi-synthétiques sur une large échelle est possible et à partir de cette étape capitale les découvertes vont se succéder : [...] synthèse de la méticilline, première pénicilline active sur les staphylocoques producteurs de pénicillinase.

Spanish

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