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SERUM RESPONSE FACTOR [1 record]

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Record 1 1997-03-20

English

Subject field(s)
  • Genetics
CONT

The principle factor responsible for the transcriptional state of the c-fos proto-oncogene is the serum response factor (SRF) which binds a conserved DNA sequence called serum response element (SRE) present in the promoter region of the c-fos gene. In order to elucidate the molecular basis of this interaction, we have solved the crystal structure of a recombinant SRF-SRE complex (Nature, 376:490-298, 1995).

French

Domaine(s)
  • Génétique
CONT

La MAP kinase activée phosphoryle des protéines kinases activées sur la protéine ribosomique S6, la p90rsk., l'activant à son tour. Ces deux kinases sont alors transférées dans le noyau. La MAP kinase phosphoryle le facteur TCF/Elk-1, un partenaire de SRF (serum response factor) qui intervient dans la stimulation de gènes appelés «à réponse ultraprécoce» dont le prototype est le gène c-fos.

Spanish

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