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SMOOTHENED GENE [1 record]
Record 1 - internal organization data 2010-04-20
Record 1, English
Record 1, Subject field(s)
- Genetics
Record 1, Main entry term, English
- Smoothened
1, record 1, English, Smoothened
correct
Record 1, Abbreviations, English
- Smo 2, record 1, English, Smo
correct
Record 1, Synonyms, English
- smoothened gene 3, record 1, English, smoothened%20gene
correct
Record 1, Textual support, English
Record number: 1, Textual support number: 1 CONT
The protein Sonic Hedgehog (Shh) controls patterning growth during vertebrate development. Here we demonstrate that it binds Patched (vPtc), which has been identified as a tumour-suppressor protein in basal cell carcinoma, with high affinity. We show that Ptc can form a physical complex with w newly cloned vertebrate homologue of the Drosophila protein Smoothened (vSmo), and that vSmo is coexpressed with vPtc in many tissues but does not bind Shh directly. 4, record 1, English, - Smoothened
Record number: 1, Textual support number: 2 CONT
Sequence analysis of the smoothened transcription reveals a single open reading frame encoding a protein with seven putative transmembrane domains. This structure is typical of G-protein-coupled receptors, suggesting that the Smoothened protein may act as a receptor for the Hegdgehog ligand. 5, record 1, English, - Smoothened
Record number: 1, Textual support number: 3 CONT
The Drosophila smoothened gene encodes a seven-pass membrane protein, a putative receptor for the Hedgehog signal. 3, record 1, English, - Smoothened
Record 1, French
Record 1, Domaine(s)
- Génétique
Record 1, Main entry term, French
- protéine Smoothened
1, record 1, French, prot%C3%A9ine%20Smoothened
correct, feminine noun
Record 1, Abbreviations, French
Record 1, Synonyms, French
- protéine Smo 2, record 1, French, prot%C3%A9ine%20Smo
proposal, feminine noun
- gène Smo 2, record 1, French, g%C3%A8ne%20Smo
proposal, masculine noun
Record 1, Textual support, French
Record number: 1, Textual support number: 1 CONT
Le signal Hedgehog et sa pathologie. Le précurseur de Sonic Hedgehog subit une maturation autoprotéolytique par liaison au cholestérol. La partie amino-terminale de Sonic Hedgehog se fixe au récepteur «patched» complexé à la protéine Smoothened. 1, record 1, French, - prot%C3%A9ine%20Smoothened
Record 1, Spanish
Record 1, Textual support, Spanish
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