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Record 1,  Textual support,  English

Record number: 1, Textual support number: 1 CONT

Addition of bacterial sphingomyelinase to quiescent Swiss 3T3 cells effectively potentiated the platelet-derived growth factor (PDGF)-stimulated cell proliferation, though the enzyme by itself had little effect on the cell proliferation. Such potentiation of the cell growth could also be observed by the addition of ceramide, a product of the sphingomyelinase-catalysed reaction. In contrast, phosphocholine, another product of the enzyme reaction, had no synergistic effect on the action of PDGF. Treatment of the cells with sphingomyelinase or ceramide increased the cellular activity of mitogen-activated protein kinases (MAP kinases), which have been implicated in the regulation of cell proliferation.  1, record 1, English, - sphingomyelinase

Record 1,  Textual support,  French

Record number: 1, Textual support number: 1 CONT

Certaines cytokines, des agents différentiateurs, ou des effecteurs antitumoraux activent une voie de transmission du signal intracellulaire caractérisée par l'hydrolyse de la sphingomyéline et production de céramide sous l'effet de sphingomyélinases.  1, record 1, French, - sphingomy%C3%A9linase

Record 1,  Textual support,  Spanish