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SUPPRESSOR HAIRLESS PROTEIN [1 record]
Record 1 - internal organization data 1997-05-07
Record 1, English
Record 1, Subject field(s)
- Genetics
- Molecular Biology
Record 1, Main entry term, English
- Su(H) protein
1, record 1, English, Su%28H%29%20protein
correct
Record 1, Abbreviations, English
Record 1, Synonyms, English
- Suppressor of Hairless protein 2, record 1, English, Suppressor%20of%20Hairless%20protein
correct
Record 1, Textual support, English
Record number: 1, Textual support number: 1 CONT
A very original set of experiments carried out by the Unit of Molecular Biology of Gene Expression concerns another protein essential for mouse development that is also a transcription factor. This factor known as KBF2 or RBP-Jk is homologous to a Drosophila gene product, Su(H) (Suppressor of Hairless), which belongs to the Notch signal transduction cascade involved in regulating the competence of a cell to respond to specific developmental cues. A likely function of the Su(H) protein is to serve as an anchor on DNA for non DNA-binding transcriptional activators. This function is conserved in the Notch pathway: the activation of this transmembrane receptor likely involves a proteolytic cleavage step which releases its intracellular domain; following nuclear translocation, it activates its target genes by binding to the Su(H) protein, which is already bound to several sites in the target promoters. 2, record 1, English, - Su%28H%29%20protein
Record 1, French
Record 1, Domaine(s)
- Génétique
- Biologie moléculaire
Record 1, Main entry term, French
- protéine Su(H)
1, record 1, French, prot%C3%A9ine%20Su%28H%29
correct, feminine noun
Record 1, Abbreviations, French
Record 1, Synonyms, French
Record 1, Textual support, French
Record number: 1, Textual support number: 1 CONT
La protéine Su(H), impliquée dans l'activité de transmission de ce signal, semble capable de s'associer à la région intracellulaire de Notch. C'est un facteur de transcription qui se lie à certaines séquences localisées dans les promoteurs de plusieurs des gènes cibles de Notch. 1, record 1, French, - prot%C3%A9ine%20Su%28H%29
Record 1, Spanish
Record 1, Textual support, Spanish
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