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THYROID-STIMULATING IMMUNOGLOBULIN [1 record]
Record 1 - internal organization data 1993-03-11
Record 1, English
Record 1, Subject field(s)
- Immunology
Record 1, Main entry term, English
- thyroid-stimulating immunoglobulin 1, record 1, English, thyroid%2Dstimulating%20immunoglobulin
Record 1, Abbreviations, English
Record 1, Synonyms, English
- human thyroid adenylate cyclase stimulators 1, record 1, English, human%20thyroid%20adenylate%20cyclase%20stimulators
- long acting thyroid stimulator 1, record 1, English, long%20acting%20thyroid%20stimulator
Record 1, Textual support, English
Record number: 1, Textual support number: 1 DEF
Circulating IgG antibodies with the ability to mimic TSH (thyroid-stimulating hormone, thyrotropin) by binding to the TSH receptor of thyroid cells and activating adenylate cyclase, thus causing an increase in the level of intracellular second messenger cyclic AMP, which results in the release of thyroid hormones, thought to be responsible for most cases of Graves' disease. 1, record 1, English, - thyroid%2Dstimulating%20immunoglobulin
Record 1, French
Record 1, Domaine(s)
- Immunologie
Record 1, Main entry term, French
- facteur IgG stimulant les fonctions thyroïdiennes
1, record 1, French, facteur%20IgG%20stimulant%20les%20fonctions%20thyro%C3%AFdiennes
masculine noun
Record 1, Abbreviations, French
Record 1, Synonyms, French
Record 1, Textual support, French
Record number: 1, Textual support number: 1 DEF
[...] anticorps spécifique (IgG)3 qui se fixe sur la membrane des cellules thyroïdiennes et stimule leur sécrétion. 3, record 1, French, - facteur%20IgG%20stimulant%20les%20fonctions%20thyro%C3%AFdiennes
Record number: 1, Textual support number: 1 CONT
C'est la mise en évidence d'un facteur IgG stimulant les fonctions thyroïdiennes, le "long acting thyroid stimulator" (LATS), qui a permis d'évoquer l'origine auto-immune de la maladie (de Basedow). Le LATS tient son nom de son action plus lente que celle de la TSH. 4, record 1, French, - facteur%20IgG%20stimulant%20les%20fonctions%20thyro%C3%AFdiennes
Record number: 1, Textual support number: 2 CONT
Le LATS est un autoanticorps qui se fixe dans la thyroïde sur des antigènes de membrane proches des sites récepteurs de l'hormone thyrostimulante, la TSH, et qui active comme celle-ci l'adénylcyclase. 2, record 1, French, - facteur%20IgG%20stimulant%20les%20fonctions%20thyro%C3%AFdiennes
Record 1, Spanish
Record 1, Textual support, Spanish
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