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ANTIBODY CLASS SWITCHING [1 record]
Record 1 - internal organization data 2012-08-31
Record 1, English
Record 1, Subject field(s)
- Immunology
Record 1, Main entry term, English
- isotype switching
1, record 1, English, isotype%20switching
correct
Record 1, Abbreviations, English
Record 1, Synonyms, English
- class switching 2, record 1, English, class%20switching
correct
- immunoglobulin class switching 3, record 1, English, immunoglobulin%20class%20switching
correct
- Ig class switching 4, record 1, English, Ig%20class%20switching
correct
- heavy-chain class switching 5, record 1, English, heavy%2Dchain%20class%20switching
correct
- antibody class switching 6, record 1, English, antibody%20class%20switching
correct
Record 1, Textual support, English
Record number: 1, Textual support number: 1 CONT
The first antibodies produced in a humoral immune response are IgM, but activated B cells subsequently undergo isotype switching or class switching to secrete antibodies of different isotypes: IgG [inmunoglobulin G], IgA, and IgE. Isotype switching does not affect antibody specificity significantly, but alters the effector functions that an antibody can engage. Isotype switching occurs by a site-specific recombination involving the deletion of the intervening DNA. 7, record 1, English, - isotype%20switching
Record 1, Key term(s)
- heavy chain class switching
Record 1, French
Record 1, Domaine(s)
- Immunologie
Record 1, Main entry term, French
- commutation isotypique
1, record 1, French, commutation%20isotypique
correct, feminine noun
Record 1, Abbreviations, French
Record 1, Synonyms, French
- commutation de classe 2, record 1, French, commutation%20de%20classe
correct, feminine noun
Record 1, Textual support, French
Record number: 1, Textual support number: 1 DEF
Processus par lequel une cellule B peut associer de nouveaux gènes de chaînes lourdes d'immunoglobulines à son gène V recombiné pour produire un anticorps de même spécificité mais de classe différente. 3, record 1, French, - commutation%20isotypique
Record number: 1, Textual support number: 1 OBS
Ce processus est aussi retrouvé dans la commutation isotypique générale que l'on observe au cours de la maturation d'une réponse immunitaire. 3, record 1, French, - commutation%20isotypique
Record 1, Spanish
Record 1, Campo(s) temático(s)
- Inmunología
Record 1, Main entry term, Spanish
- cambio de clase
1, record 1, Spanish, cambio%20de%20clase
correct, masculine noun
Record 1, Abbreviations, Spanish
Record 1, Synonyms, Spanish
Record 1, Textual support, Spanish
Record number: 1, Textual support number: 1 DEF
Proceso durante el cual una célula plasmática deja de producir anticuerpos de una clase y comienza a producirlos de otro distinta. 2, record 1, Spanish, - cambio%20de%20clase
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