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The Government of Canada’s terminology and linguistic data bank.
COMPLEMENTARITY-DETERMINING REGION GRAFTING [1 record]
Record 1 - internal organization data 2021-12-20
Record 1, English
Record 1, Subject field(s)
- Biotechnology
- Immunology
- Molecular Biology
Record 1, Main entry term, English
- complementarity-determining region grafting
1, record 1, English, complementarity%2Ddetermining%20region%20grafting
correct
Record 1, Abbreviations, English
Record 1, Synonyms, English
- CDR grafting 2, record 1, English, CDR%20grafting
correct
Record 1, Textual support, English
Record number: 1, Textual support number: 1 CONT
CDR grafting has three fundamental components: (1) delimitation of CDRs [complementarity-determining regions] as regions determining the specificity of the nonhuman antibody and hence target for grafting, (2) selection of human FRs [framework regions] to be combined with nonhuman CDRs, and (3) assessment of conflicts between nonhuman CDRs and human FRs and design of back mutations to prevent a loss of affinity in the final product. 3, record 1, English, - complementarity%2Ddetermining%20region%20grafting
Record number: 1, Textual support number: 1 OBS
CDR grafting is the most frequently used rational design strategy for antibody humanization ... 4, record 1, English, - complementarity%2Ddetermining%20region%20grafting
Record 1, French
Record 1, Domaine(s)
- Biotechnologie
- Immunologie
- Biologie moléculaire
Record 1, Main entry term, French
- greffage de régions déterminant la complémentarité
1, record 1, French, greffage%20de%20r%C3%A9gions%20d%C3%A9terminant%20la%20compl%C3%A9mentarit%C3%A9
masculine noun
Record 1, Abbreviations, French
Record 1, Synonyms, French
- greffage de régions déterminantes de la complémentarité 1, record 1, French, greffage%20de%20r%C3%A9gions%20d%C3%A9terminantes%20de%20la%20compl%C3%A9mentarit%C3%A9
masculine noun
- greffage de CDR 2, record 1, French, greffage%20de%20CDR
masculine noun
- greffage de régions CDR 3, record 1, French, greffage%20de%20r%C3%A9gions%20CDR
masculine noun
Record 1, Textual support, French
Record 1, Spanish
Record 1, Campo(s) temático(s)
- Biotecnología
- Inmunología
- Biología molecular
Record 1, Main entry term, Spanish
- trasplante de las regiones determinantes de la complementariedad
1, record 1, Spanish, trasplante%20de%20las%20regiones%20determinantes%20de%20la%20complementariedad
correct, masculine noun
Record 1, Abbreviations, Spanish
Record 1, Synonyms, Spanish
Record 1, Textual support, Spanish
Record number: 1, Textual support number: 1 CONT
El Nimotuzumab, o h-R3, es un anticuerpo humanizado contra el receptor del factor de crecimiento epidérmico (EGF-R), generado mediante el trasplante de las regiones determinantes de la complementariedad o regiones hipervariables del anticuerpo murinoioregf/r3, en un marco de soporte de una inmunoglobulina humana. 1, record 1, Spanish, - trasplante%20de%20las%20regiones%20determinantes%20de%20la%20complementariedad
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