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DIHYDROFOLATE REDUCTASE [1 record]

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Record 1 2002-01-10

English

Subject field(s)
  • Biochemistry
CONT

The dihydrofolate reductase amplicons in different methotrexate-resistant chinese hamster cell lines share at least a 273-kilobase core sequence, but the amplicons in some cell lines are much larger and are remarkably uniform in structure.

OBS

Tiré de: Molecular and cellular biology, 1988, 8 (12), 5268-5279.

French

Domaine(s)
  • Biochimie
CONT

[...] L'amplification de régions d'ADN contenant un gène permettant de résister à un agent de sélection est-elle observée in vitro dans divers systèmes eucaryotes : résistance au méthotrexate (MTX) et amplification du gène codant pour la dihydrofolate réductase (DHFR), résistance au N-(phosphonacétyl)-L-aspartate (PALA) et amplification du gène codant pour la protéine trifonctionnelle CAD.

Spanish

Campo(s) temático(s)
  • Bioquímica
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