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METAGENOMIC ACIDIC LIPOPEPTIDE ANTIBIOTIC-CIDIN [1 record]

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Record 1 2018-05-17

English

Subject field(s)
  • Medication
CONT

... the discovery of the malacidins, a distinctive class of antibiotics that are commonly encoded in soil microbiomes but have never been reported in culture-based NP [natural product] discovery efforts. The malacidins are active against multidrug-resistant pathogens, sterilize methicillin-resistant Staphylococcus aureus skin infections in an animal wound model and did not select for resistance under our laboratory conditions.

French

Domaine(s)
  • Médicaments
CONT

Ces antibiotiques, [...] nommés malacidines (metagenomic acidic lipopeptide antibiotic-cidins), ont [...] démontré une puissante activité antibactérienne contre des pathogènes résistants aux antibiotiques utilisés en clinique, y compris l'antibiotique de dernier recours vancomycine. Ils parvenaient même à éliminer définitivement le fameux Staphylococcus Aureus résistant à la méthicilline (SARM) présent dans des blessures cutanées chez l’animal.

Spanish

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