TERMIUM Plus®

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PUVA THERAPY [1 record]

Record 1 2003-07-25

English

Subject field(s)
  • Non-Surgical Treatment
  • Epidermis and Dermis
DEF

A treatment involving exposing patients to ultraviolet radiation after they have taken methoxsalen (8-MOP).

CONT

Recently there has been a rapid development in the world-wide use of oral and topical methoxsalen (8-methoxypsoralen; 8-MOP) with long wave ultraviolet light (UVA) for treating patients with psoriasis. This form of photochemotherapy is known as PUVA treatment, and is effective in clearing and maintaining a remission of psoriasis in most patients treated.

OBS

The light activates the drug, which then binds to DNA and causes cell death. Since the effects are confines to the skin, this is a treatment for mycosis fungoides as well as other skin disorders. A possible side effect of this treatment is the development of secondary skin cancers.

French

Domaine(s)
  • Traitements non chirurgicaux
  • Épiderme et derme
CONT

Il semble que la PUVA thérapie provoque une inhibition de la kératinisation anormale, probablement due à un gène de réflexion et que ce phénomène puisse être relié à des modifications des centres fibrillaires du nucléole du kératinocyte psoriasique.

OBS

«puvathérapie» : Relevé dans Biofutur, numéro 114, juillet-août 1992, page 35.

Spanish

Campo(s) temático(s)
  • Tratamiento sin cirugía
  • Epidermis y dermis
DEF

Tratamiento que consiste en la exposición del paciente a radiación ultravioleta, una vez que haya ingerido [o aplicado en la piel] methoxsalen (8-MOP).

OBS

La luz ultravioleta activa el fármaco, que a continuación, se liga al ADN, produciendo la muerte celular en el área afectada. Puesto que sólo se afecta la piel, esto es un tratamiento para la micosis fungoide, así como para otras alteraciones de la piel. Un posible efecto secundario de este tratamiento es el desarrollo de cánceres de la piel secundarios.

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