TERMIUM Plus®

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HIRULOGS [1 record]

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Record 1 2010-06-09

English

Subject field(s)
  • Biochemistry
CONT

Using the natural protein hirudin as a model, a novel class of synthetic peptide inhibitors were recently designed. These inhibitors, ’hirulogs’, retain the carboxy terminal Hir53-64 domain that interacts with the anion binding exosite of thrombin, connected via an oligoglycyl spacer unit to a catalytic site-directed moiety modeled on the sequence(d) Phe-Pro-Arg-X.

French

Domaine(s)
  • Biochimie

Spanish

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