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RO 5-3335 [1 record]

Record 1 1996-10-31

English

Subject field(s)
  • Medication
CONT

7-chloro-5-(2-pyrryl)-3H-1,4 benzodiazapin-2-(H)-one) (Ro 5-3335) and (7-chloro-5-(1H-pyrrol-2-yl)-3H-ben zo(e) (1,4) diazepin-2-yl)-methylamine (Ro 24-7429), inhibit human immunodeficiency virus type 1 (HIV-1) replication via a specific effect on the function of the transactivator protein, Tat.

French

Domaine(s)
  • Médicaments
CONT

Hoffman-La Roche dispose d'ores et déjà d'un inhibiteur de Tat efficace in vitro, qui montre une faible toxicité, et une synergie d'action avec l'AZT. Ce composé, le RO 24-7429, est une benzodiazépine. Une deuxième molécule, le RO 5-3335, est à l'étude.

Spanish

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