TERMIUM Plus^®

Fiche 1,  Justifications,  Anglais

Record number: 1, Textual support number: 1 CONT

The molecular basis of beta thalassemia in Lebanon has previously been studied in a sample of 25 homozygote individuals. The 25 individuals included in that study had all presented at the American University Hospital and, with the exception of one patient, were all of the Muslim religion. With the advent of PCR, new techniques for mutation screening have emerged, among them the Allele Refractory Mutation System(ARMS) based on allele-specific priming of the amplification reaction. We are currently applying this technique in our laboratory in order to screen a larger number of samples from heterozygote individuals, in an effort to complement the previous findings and study the distribution of mutations among different geographical regions and different religious groups...  3, fiche 1, Anglais, - amplification%20refractory%20mutation%20system%2DPCR

Fiche 1,  Justifications,  Français

Record number: 1, Textual support number: 1 CONT

L'ARMS-PCR (amplification refractory mutation system) et la STR-PCR (single tandem repeat) occupent d'ores et déjà une place importante dans le diagnostic des maladies héréditaires et des cancers. Toutes les deux impliquent l'amplification par PCR de loci génomiques spécifiques grâce à l'utilisation d'amorces permettant de discriminer des mutations ponctuelles (ARMS-PCR) ou des répétitions en tandem localisées sur un locus particulier (STR-PCR).  2, fiche 1, Français, - m%C3%A9thode%20ARMS%2DPCR

Record number: 1, Textual support number: 1 OBS

Méthode d'analyse du génome à des fins diagnostiques.  1, fiche 1, Français, - m%C3%A9thode%20ARMS%2DPCR

Fiche 1,  Justifications,  Espagnol

Fiche 2,  Justifications,  Anglais

Record number: 2, Textual support number: 1 CONT

Several laboratory sections, ranging from routine chemistry to molecular diagnosis of CVD risk factors, offer a full comprehensive array of unique and rare tests as well as traditional analyses services for patients at UMHC and hospitals and clinics in the Twin Cities area. Techniques used : Abell-Kendall cholesterol analysis, GC/MS cholesterol analysis, apolipoprotein E genotyping by amplification refractory mutation system(ARMS), plasma fatty acid analysis by capillary GC.  3, fiche 2, Anglais, - amplification%20refractory%20mutation%20system

Fiche 2,  Justifications,  Français

Record number: 2, Textual support number: 1 CONT

La même équipe vient d'adopter une stratégie astucieuse, beaucoup plus efficace et généralisable à l'analyse de toute néomutation. Intitulée ARMS (amplification refractory mutation system), elle consiste, après avoir repéré des variants normaux proches du site de mutation, à réaliser en PCR des amplifications sélectives en choisissant les amorces et les enzymes de restriction.  1, fiche 2, Français, - analyse%20ARMS

Fiche 2,  Justifications,  Espagnol