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The stress-activated protein kinases (SAPKs), which are distantly related to the MAP kinases, are the dominant c-Jun amino-terminal protein kinases activated in response to a variety of cellular stresses, including treatment with tumour-necrosis factor-alpha and interleukin-beta[...] We have now identified a novel protein kinase, called SAPK/ERK kinase-1 (SEK1), which is structurally related to the MAP kinase kinases (MEKs). SEK1 is a potent activator of the SAPKs in vitro and in vivo.  3, fiche 1, Anglais, - SAPK%2FERK%20kinase%2D1

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Role of SAPK/ERK kinase-1 in the stress-activated pathway regulating transcription factor c-Jun. Excerpt from Nature 372, 794-8, 1994.  4, fiche 1, Anglais, - SAPK%2FERK%20kinase%2D1

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