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The DNA-binding domains appear to have well-defined structural motifs: by contrast, mutational studies of the activator domains suggest a disquieting picture of a conformationally ill-defined polypeptide that can function almost irrespective of sequence, provided only that there is a sufficient excess of acidic residues clustered or peppered about. Thus, the elegant molecular machinery that so reliably controls expression of eukaryotic polymerase II-transcribed genes relies on nearly shapeless molecular components dubbed "acid blobs" or perhaps more aptly "negative noodles".  1, fiche 1, Anglais, - acid%20blob

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Record number: 2, Textual support number: 1 CONT

... ill-defined polypeptide that can function almost irrespective of sequence, provided only that there is a sufficient excess of acidic residues clustered or peppered about. Thus, the elegant molecular machinery ... relies on nearly shapeless molecular components dubbed "acid blobs" or perhaps more aptly "negative noodles".  1, fiche 2, Anglais, - negative%20noodle

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