TERMIUM Plus^®

Fiche 1,  Justifications,  Anglais

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In another application of gene therapy we have used an adenoviral vector that carries the gene for herpes simplex virus thymidine kinase (HSV-tk). Cells expressing HSV-tk will convert the anti-viral drug ganciclovir (GCV) to a form that is toxic to rapidly dividing cells. Using this adenoviral vector we have repeatedly shown robust tumoricidal effects in a variety of animal models of CNS tumor and will soon take this treatment to phase I clinical trials. We are extending this work to the manipulation of the CNSs immune response to tumors using adenoviral vectors that carry several cytokine genes.  1, fiche 1, Anglais, - herpes%20simplex%20virus%20thymidine%20kinase

Fiche 1,  Justifications,  Français

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Traitement du glioblastome multiforme - une tumeur létale du cerveau - par transduction tumorale in vivo du gène codant la thymidine kinase du virus herpès simplex (HSV-TK), suivie par l'administration de ganciclovir, tel est l'intitulé des essais cliniques de phase II qui ont débuté en juin dernier en Belgique.  1, fiche 1, Français, - thimidine%20kinase%20du%20virus%20herp%C3%A8s%20simplex

Fiche 1,  Justifications,  Espagnol