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OLIGOMERIC ENZYME [1 record]
Record 1 - internal organization data 2011-02-09
Record 1, English
Record 1, Subject field(s)
- Biological Sciences
Record 1, Main entry term, English
- oligomeric enzyme
1, record 1, English, oligomeric%20enzyme
correct
Record 1, Abbreviations, English
Record 1, Synonyms, English
Record 1, Textual support, English
Record number: 1, Textual support number: 1 DEF
Enzyme composed of identical subunits or unlike subunits. 2, record 1, English, - oligomeric%20enzyme
Record number: 1, Textual support number: 1 CONT
Oligomeric enzymes are usually dissociated into subunits by treatment with denaturing agents such as guanidine hydrochloride. The forces involved in the association of the subunits are thus of the weak, non-covalent type which are involved in stabilizing the folded structure of a polypeptide chain i.e. hydrogen bonds, electrostatic forces, van der Waals forces, and hydrophobic forces. 3, record 1, English, - oligomeric%20enzyme
Record number: 1, Textual support number: 1 OBS
Many investigators in the late sixties questioned the very existence of uneven numbered oligomers. However, by now we know of well-defined cases for trimeric enzymes.... Pentameric enzymes are rare, whereas no heptamer has so far been found. It is therefore justifiable to say that even-numbered oligomers are much more common than those having an uneven number of protomers, but the latter also exist.... Very few true oligomeric enzymes contain ten, twelve or more subunits. 1, record 1, English, - oligomeric%20enzyme
Record 1, French
Record 1, Domaine(s)
- Sciences biologiques
Record 1, Main entry term, French
- enzyme oligomère
1, record 1, French, enzyme%20oligom%C3%A8re
correct, feminine noun
Record 1, Abbreviations, French
Record 1, Synonyms, French
Record 1, Textual support, French
Record number: 1, Textual support number: 1 DEF
Enzyme [...] formé de plusieurs chaînes (ou sous-unités) identiques ou différentes. Lorsque les enzymes comprennent des sous-unités identiques, chacune des chaînes est bien entendu porteuse d'un centre actif : un enzyme tétramérique a 4 centres actifs. Dans cette catégorie d'enzymes [...] on trouve les enzymes allostériques (qui représentent 10-20 % des enzymes à structure quaternaire). 1, record 1, French, - enzyme%20oligom%C3%A8re
Record number: 1, Textual support number: 1 CONT
Dans le modèle de Monod, Wyman et Changeux, l'enzyme oligomère peut prendre deux états conformationnels différents : R et T dans lesquels, toutes les sous-unités changent leur conformation d'une façon concertée. Les deux états sont en équilibre. En l'absence de substrat, la plus grande partie des molécules de l'enzyme prennent l'état T. Puisque le substrat se lie de préférence à l'état R, l'addition du substrat déplace l'équilibre vers cet état R. De cette façon, la liaison des premières molécules du substrat favorise la liaison de celles qui suivent, étant donné que plus de molécules enzymatiques prennent l'état R. 2, record 1, French, - enzyme%20oligom%C3%A8re
Record 1, Spanish
Record 1, Textual support, Spanish
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