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MHC [41 records]
Record 1 - internal organization data 2026-03-18
Record 1, English
Record 1, Subject field(s)
- Genetics
- Biochemistry
- Microbiology and Parasitology
- Immunology
Record 1, Main entry term, English
- major histocompatibility complex
1, record 1, English, major%20histocompatibility%20complex
correct, noun
Record 1, Abbreviations, English
- MHC 2, record 1, English, MHC
correct, noun
Record 1, Synonyms, English
Record 1, Textual support, English
Record number: 1, Textual support number: 1 CONT
The major histocompatibility complex(MHC) is a cluster of functionally related genes encoding proteins which, among other functions, mediate immune system activation. 3, record 1, English, - major%20histocompatibility%20complex
Record 1, French
Record 1, Domaine(s)
- Génétique
- Biochimie
- Microbiologie et parasitologie
- Immunologie
Record 1, Main entry term, French
- complexe majeur d'histocompatibilité
1, record 1, French, complexe%20majeur%20d%27histocompatibilit%C3%A9
correct, masculine noun
Record 1, Abbreviations, French
- CMH 2, record 1, French, CMH
correct, masculine noun
Record 1, Synonyms, French
Record 1, Textual support, French
Record number: 1, Textual support number: 1 DEF
Région du génome des vertébrés regroupant l'information génétique qui code des protéines présentes sur la face externe de la membrane plasmique, responsables de la reconnaissance du soi et permettant la réponse immunitaire. 3, record 1, French, - complexe%20majeur%20d%27histocompatibilit%C3%A9
Record number: 1, Textual support number: 1 OBS
complexe majeur d'histocompatibilité; CMH : désignations et définition publiées au Journal officiel de la République française le 9 avril 2022. 4, record 1, French, - complexe%20majeur%20d%27histocompatibilit%C3%A9
Record 1, Spanish
Record 1, Campo(s) temático(s)
- Genética
- Bioquímica
- Microbiología y parasitología
- Inmunología
Record 1, Main entry term, Spanish
- complejo mayor de histocompatibilidad
1, record 1, Spanish, complejo%20mayor%20de%20histocompatibilidad
correct, masculine noun
Record 1, Abbreviations, Spanish
Record 1, Synonyms, Spanish
Record 1, Textual support, Spanish
Record number: 1, Textual support number: 1 DEF
Conjunto de genes que controlan aspectos de la respuesta inmune, produciendo antígenos histocompatibles, que están presentes en todas las células del cuerpo como marcadores para identificarlas como propias. 1, record 1, Spanish, - complejo%20mayor%20de%20histocompatibilidad
Record 2 - internal organization data 2026-02-24
Record 2, English
Record 2, Subject field(s)
- Immunology
- Molecular Biology
Record 2, Main entry term, English
- immunopeptidomics
1, record 2, English, immunopeptidomics
correct, noun
Record 2, Abbreviations, English
Record 2, Synonyms, English
Record 2, Textual support, English
Record number: 2, Textual support number: 1 CONT
Immunopeptidomics combines proteomics and immunology to study the antigen repertoire, or the immunopeptidome, by assessing MHC [major histocompatibility complex] bound peptides isolated from biological samples using mass spectrometry for quantitative analysis and characterization.... Immunopeptidomics aids in understanding disease pathogenesis, particularly autoimmune disease and cancers, by using mass spectrometry to quantitatively analyze MHC associated peptides in the immunopeptidome. 1, record 2, English, - immunopeptidomics
Record 2, French
Record 2, Domaine(s)
- Immunologie
- Biologie moléculaire
Record 2, Main entry term, French
- immunopeptidomique
1, record 2, French, immunopeptidomique
correct, feminine noun
Record 2, Abbreviations, French
Record 2, Synonyms, French
Record 2, Textual support, French
Record number: 2, Textual support number: 1 CONT
L'immunopeptidomique est un domaine émergent se référant à la science qui étudie l'ensemble des peptides (ou ligands) liés aux molécules du complexe majeur d'histocomptabilité (CMH). Ces peptides jouent un rôle fondamental dans la réponse immunitaire médiée par les lymphocytes T, et représentent donc des cibles de choix pour le développement de vaccins ou d'immunothérapies contre le cancer, les maladies auto-immunes et infectieuses. 1, record 2, French, - immunopeptidomique
Record 2, Spanish
Record 2, Campo(s) temático(s)
- Inmunología
- Biología molecular
Record 2, Main entry term, Spanish
- inmunopeptidómica
1, record 2, Spanish, inmunopeptid%C3%B3mica
correct, feminine noun
Record 2, Abbreviations, Spanish
Record 2, Synonyms, Spanish
Record 2, Textual support, Spanish
Record number: 2, Textual support number: 1 CONT
La inmunopeptidómica, como el análisis de péptidos antigénicos que se presentan al sistema inmunológico a través de complejos mayores de histocompatibilidad (MHC), se está viendo como una herramienta imperativa para identificar epítopos para el desarrollo de vacunas para tratar el cáncer, así como infecciones virales, bacterianas y parásitos. 1, record 2, Spanish, - inmunopeptid%C3%B3mica
Record 3 - internal organization data 2025-01-31
Record 3, English
Record 3, Subject field(s)
- Military Administration
- Personnel Management
Record 3, Main entry term, English
- military high command
1, record 3, English, military%20high%20command
correct, noun, NATO, standardized
Record 3, Abbreviations, English
- MHC 2, record 3, English, MHC
correct, noun, NATO, standardized
Record 3, Synonyms, English
Record 3, Textual support, English
Record number: 3, Textual support number: 1 OBS
military high command; MHC : designations standardized by NATO. 3, record 3, English, - military%20high%20command
Record 3, French
Record 3, Domaine(s)
- Administration militaire
- Gestion du personnel
Record 3, Main entry term, French
- haut commandement militaire
1, record 3, French, haut%20commandement%20militaire
correct, masculine noun, NATO, standardized
Record 3, Abbreviations, French
Record 3, Synonyms, French
Record 3, Textual support, French
Record number: 3, Textual support number: 1 OBS
haut commandement militaire : désignation normalisée par l'OTAN. 2, record 3, French, - haut%20commandement%20militaire
Record 3, Spanish
Record 3, Textual support, Spanish
Record 4 - internal organization data 2023-02-20
Record 4, English
Record 4, Subject field(s)
- Types of Ships and Boats
- Minesweeping and Minehunting
Record 4, Main entry term, English
- minehunter, coastal
1, record 4, English, minehunter%2C%20coastal
correct, NATO, standardized
Record 4, Abbreviations, English
- MHC 2, record 4, English, MHC
correct, NATO, standardized
Record 4, Synonyms, English
- coastal minehunter 3, record 4, English, coastal%20minehunter
correct
Record 4, Textual support, English
Record number: 4, Textual support number: 1 DEF
[A ship that is] designed to find, classify and destroy moored and bottom mines from vital waterways. 3, record 4, English, - minehunter%2C%20coastal
Record number: 4, Textual support number: 1 OBS
Coastal minehunters are generally smaller and with lower sea-keeping and endurance than oceangoing minehunters. They are usually tasked with keeping fixed high-value choke points clear of mines, such as the approaches to military ports and harbours. 3, record 4, English, - minehunter%2C%20coastal
Record number: 4, Textual support number: 2 OBS
minehunter, coastal; MHC : designations standardized by NATO. 4, record 4, English, - minehunter%2C%20coastal
Record 4, Key term(s)
- coastal mine hunter
- mine hunter, coastal
Record 4, French
Record 4, Domaine(s)
- Types de bateaux
- Dragage et chasse aux mines
Record 4, Main entry term, French
- chasseur de mines côtier
1, record 4, French, chasseur%20de%20mines%20c%C3%B4tier
correct, masculine noun, NATO, standardized
Record 4, Abbreviations, French
Record 4, Synonyms, French
Record 4, Textual support, French
Record number: 4, Textual support number: 1 OBS
chasseur de mines côtier : désignation normalisée par l'OTAN. 2, record 4, French, - chasseur%20de%20mines%20c%C3%B4tier
Record 4, Spanish
Record 4, Textual support, Spanish
Record 5 - internal organization data 2019-10-25
Record 5, English
Record 5, Subject field(s)
- Immunology
Record 5, Main entry term, English
- human leukocyte antigen
1, record 5, English, human%20leukocyte%20antigen
correct
Record 5, Abbreviations, English
- HLA 2, record 5, English, HLA
correct
Record 5, Synonyms, English
Record 5, Textual support, English
Record number: 5, Textual support number: 1 OBS
Major histocompatibility complex(MHC) molecule expressed on the surface of human cells. 3, record 5, English, - human%20leukocyte%20antigen
Record number: 5, Textual support number: 1 CONT
In the case of allogeneic transplants, identifying a potential donor who can give their stem cells to another person involves analyzing the human leukocyte antigens (HLA), which are proteins found on the surface of the blood and in tissue cells. The HLA must be as closely matched as possible so that the transplant recipient’s body can "accept" the new stem cells into their bone marrow. Just as important, matching at HLA will decrease the chance of the new marrow reacting against the patient, a reaction called graft versus host disease. 4, record 5, English, - human%20leukocyte%20antigen
Record 5, French
Record 5, Domaine(s)
- Immunologie
Record 5, Main entry term, French
- antigène leucocytaire humain
1, record 5, French, antig%C3%A8ne%20leucocytaire%20humain
correct, masculine noun
Record 5, Abbreviations, French
Record 5, Synonyms, French
- antigène des leucocytes humains 2, record 5, French, antig%C3%A8ne%20des%20leucocytes%20humains
correct, masculine noun
- antigène HLA 3, record 5, French, antig%C3%A8ne%20HLA
correct, masculine noun
Record 5, Textual support, French
Record number: 5, Textual support number: 1 CONT
Dans le cas des allogreffes, il faut faire une analyse des antigènes leucocytaires humains (antigènes HLA) pour identifier une personne susceptible de donner des cellules souches à une autre personne. Ces antigènes sont des protéines présentes à la surface des cellules sanguines et dans les cellules des tissus. Les antigènes HLA doivent être les plus semblables possible pour que le corps du receveur «accepte» les nouvelles cellules souches dans sa moelle osseuse. La compatibilité HLA diminuera aussi les risques que la nouvelle moelle réagisse contre le patient, ce que l'on appelle «réaction du greffon contre l'hôte». 4, record 5, French, - antig%C3%A8ne%20leucocytaire%20humain
Record 5, Spanish
Record 5, Campo(s) temático(s)
- Inmunología
Record 5, Main entry term, Spanish
- antígeno de los leucocitos humanos
1, record 5, Spanish, ant%C3%ADgeno%20de%20los%20leucocitos%20humanos
correct, masculine noun
Record 5, Abbreviations, Spanish
- ALH 1, record 5, Spanish, ALH
correct, masculine noun
Record 5, Synonyms, Spanish
Record 5, Textual support, Spanish
Record number: 5, Textual support number: 1 DEF
Marca que identifica a la célula propia del organismo para prevenir que el sistema inmunitario la ataque. 1, record 5, Spanish, - ant%C3%ADgeno%20de%20los%20leucocitos%20humanos
Record 6 - internal organization data 2018-12-04
Record 6, English
Record 6, Subject field(s)
- Occupation Names (General)
- Aircraft Piloting and Navigation
- Helicopters (Military)
Record 6, Main entry term, English
- maritime helicopter co-pilot 1, record 6, English, maritime%20helicopter%20co%2Dpilot
Record 6, Abbreviations, English
Record 6, Synonyms, English
Record 6, Textual support, English
Record number: 6, Textual support number: 1 CONT
One MHC [maritime helicopter captain] is required to do a head run. In addition, a maritime helicopter co-pilot(MHCP) is authorized to do a head run with one of the following personnel occupying the left seat... 2, record 6, English, - maritime%20helicopter%20co%2Dpilot
Record 6, Key term(s)
- maritime helicopter copilot
Record 6, French
Record 6, Domaine(s)
- Désignations des emplois (Généralités)
- Pilotage et navigation aérienne
- Hélicoptères (Militaire)
Record 6, Main entry term, French
- copilote d’hélicoptère maritime
1, record 6, French, copilote%20d%26rsquo%3Bh%C3%A9licopt%C3%A8re%20maritime
masculine noun
Record 6, Abbreviations, French
- CPHM 1, record 6, French, CPHM
masculine noun
Record 6, Synonyms, French
Record 6, Textual support, French
Record number: 6, Textual support number: 1 CONT
Il faut un CdB HM [Commandant de bord d’hélicoptères maritimes] pour effectuer un essai du rotor principal. De plus, un copilote d’hélicoptère maritime (CPHM) est autorisé à faire un essai du rotor principal avec l’un des membres suivants dans le siège de gauche [...] 2, record 6, French, - copilote%20d%26rsquo%3Bh%C3%A9licopt%C3%A8re%20maritime
Record 6, Spanish
Record 6, Textual support, Spanish
Record 7 - internal organization data 2014-10-29
Record 7, English
Record 7, Subject field(s)
- Immunology
Record 7, Main entry term, English
- immunopeptidome
1, record 7, English, immunopeptidome
correct
Record 7, Abbreviations, English
Record 7, Synonyms, English
Record 7, Textual support, English
Record number: 7, Textual support number: 1 CONT
Self/non-self discrimination is a fundamental requirement of life. Endogenous peptides presented by major histocompatibility complex class I(MHC I) molecules represent the essence of self for CD8 T lymphocytes. These MHC I peptides(MIPs) are collectively referred to as the immunopeptidome. 2, record 7, English, - immunopeptidome
Record 7, French
Record 7, Domaine(s)
- Immunologie
Record 7, Main entry term, French
- immunopeptidome
1, record 7, French, immunopeptidome
correct, masculine noun
Record 7, Abbreviations, French
Record 7, Synonyms, French
Record 7, Textual support, French
Record number: 7, Textual support number: 1 CONT
La différentiation entre le «soi» et le «non-soi» est un processus biologique essentiel à la vie. Les peptides endogènes présentés par les complexes majeurs d’histocompatibilité de classe I (CMH I) représentent le fondement du «soi» pour les lymphocytes T CD8+. On donne le nom d’immunopeptidome à l’ensemble des peptides présentés à la surface cellulaire par les molécules du CMH I. 2, record 7, French, - immunopeptidome
Record 7, Spanish
Record 7, Textual support, Spanish
Record 8 - internal organization data 2012-09-10
Record 8, English
Record 8, Subject field(s)
- Genetics
- Immunology
Record 8, Main entry term, English
- T lymphocyte antigen receptor
1, record 8, English, T%20lymphocyte%20antigen%20receptor
correct
Record 8, Abbreviations, English
Record 8, Synonyms, English
- T-cell receptor 1, record 8, English, T%2Dcell%20receptor
correct
- TCR 1, record 8, English, TCR
correct
- TCR 1, record 8, English, TCR
- T lymphocyte receptor 1, record 8, English, T%20lymphocyte%20receptor
correct
Record 8, Textual support, English
Record number: 8, Textual support number: 1 DEF
A molecule on the surface membrane of T lymphocytes capable of specifically binding antigen in association with MHC [major histocompatibility complex], leading to activation of the cell... 1, record 8, English, - T%20lymphocyte%20antigen%20receptor
Record 8, French
Record 8, Domaine(s)
- Génétique
- Immunologie
Record 8, Main entry term, French
- récepteur de l'antigène des lymphocytes T
1, record 8, French, r%C3%A9cepteur%20de%20l%27antig%C3%A8ne%20des%20lymphocytes%20T
correct, masculine noun
Record 8, Abbreviations, French
- TCR 2, record 8, French, TCR
correct
Record 8, Synonyms, French
Record 8, Textual support, French
Record number: 8, Textual support number: 1 CONT
Des récepteurs spécifiques exprimés par les cellules immuno-compétentes reconnaissent les antigènes : l'immunoglobuline membranaire exprimée par les lymphocytes B (BcR) les reconnaît sous forme soluble; le récepteur de l'antigène des lymphocytes T (TcR) reconnaît le complexe peptide antigénique-CMH [complexe majeur d'histocompatibilité] exprimé à la surface des cellules présentatrices. 1, record 8, French, - r%C3%A9cepteur%20de%20l%27antig%C3%A8ne%20des%20lymphocytes%20T
Record 8, Spanish
Record 8, Campo(s) temático(s)
- Genética
- Inmunología
Record 8, Main entry term, Spanish
- receptor de células T
1, record 8, Spanish, receptor%20de%20c%C3%A9lulas%20T
correct, masculine noun
Record 8, Abbreviations, Spanish
Record 8, Synonyms, Spanish
Record 8, Textual support, Spanish
Record number: 8, Textual support number: 1 DEF
Proteína de unión a un antígeno, localizada en la superficie de los linfocitos citolíticos de los mamíferos, que actúa como un mediador en la respuesta inmunitaria celular. 1, record 8, Spanish, - receptor%20de%20c%C3%A9lulas%20T
Record number: 8, Textual support number: 1 CONT
Los genes que codifican las regiones variables de las células T (donde se encuentran los centros de unión al antígeno) se agrupan a partir de segmentos génicos mediante procesos de recombinación somática que tienen lugar durante la diferenciación de los linfocitos. 1, record 8, Spanish, - receptor%20de%20c%C3%A9lulas%20T
Record 9 - internal organization data 2012-06-26
Record 9, English
Record 9, Subject field(s)
- Immunology
Record 9, Main entry term, English
- desetope 1, record 9, English, desetope
Record 9, Abbreviations, English
Record 9, Synonyms, English
Record 9, Textual support, English
Record number: 9, Textual support number: 1 DEF
This is the part of the MHC(major histocompatibility complex) molecule which binds to the antigen. It determines the orientation of the antigen and so which part will be presented to the T cell(derivation : determinant selection). Allotypically different class 2 molecules with different desetopes would vary in the way they associate with antigen and thus in how they stimulate T cells. In this way they could determine immune response(Ir genes). 2, record 9, English, - desetope
Record 9, French
Record 9, Domaine(s)
- Immunologie
Record 9, Main entry term, French
- désétope
1, record 9, French, d%C3%A9s%C3%A9tope
masculine noun
Record 9, Abbreviations, French
Record 9, Synonyms, French
Record 9, Textual support, French
Record number: 9, Textual support number: 1 DEF
Partie de la molécule du CMH associée à l'antigène ou à l'antigène digéré. 2, record 9, French, - d%C3%A9s%C3%A9tope
Record number: 9, Textual support number: 1 OBS
Déterminant de l'histotope. 3, record 9, French, - d%C3%A9s%C3%A9tope
Record 9, Spanish
Record 9, Campo(s) temático(s)
- Inmunología
Record 9, Main entry term, Spanish
- desetopo
1, record 9, Spanish, desetopo
correct, masculine noun
Record 9, Abbreviations, Spanish
Record 9, Synonyms, Spanish
Record 9, Textual support, Spanish
Record 10 - internal organization data 2011-11-07
Record 10, English
Record 10, Subject field(s)
- Immunology
Record 10, Main entry term, English
- immunological receptor
1, record 10, English, immunological%20receptor
correct
Record 10, Abbreviations, English
Record 10, Synonyms, English
- immunologic receptor 1, record 10, English, immunologic%20receptor
correct
- immumoreceptor 2, record 10, English, immumoreceptor
correct
Record 10, Textual support, English
Record number: 10, Textual support number: 1 DEF
A cell surface molecules on cell of the immune system that specifically binds surface molecules or messenger molecules and trigger changes in the behavior of cells. 1, record 10, English, - immunological%20receptor
Record number: 10, Textual support number: 1 CONT
Cells of the immune system expres s a wide variety of receptors, defined as immunoreceptors. These receptors are involved in antigen recognition, B and T lymphocytes express clonally distributed receptors which recognize soluble antigen for the B cell receptor(BcR) or peptide associated to major histocompatibility complex(MHC) molecules for the T cell receptor(TcR). 3, record 10, English, - immunological%20receptor
Record number: 10, Textual support number: 1 OBS
Although these receptors were first identified in the immune system, many have important functions elsewhere. 1, record 10, English, - immunological%20receptor
Record 10, French
Record 10, Domaine(s)
- Immunologie
Record 10, Main entry term, French
- récepteur immunologique
1, record 10, French, r%C3%A9cepteur%20immunologique
correct, masculine noun
Record 10, Abbreviations, French
Record 10, Synonyms, French
- immunorécepteur 2, record 10, French, immunor%C3%A9cepteur
correct, masculine noun
Record 10, Textual support, French
Record number: 10, Textual support number: 1 DEF
Récepteur spécifique exprimé par les cellules immunocompétentes. 3, record 10, French, - r%C3%A9cepteur%20immunologique
Record number: 10, Textual support number: 1 CONT
Signalisation et transport cellulaire des immunorécepteurs. Des récepteurs spécifiques exprimés par les cellules immunocompétentes reconnaissent les antigènes: l'immunoglobuline membranaire exprimée par les lymphocytes B (BcR) les reconnaît sous forme soluble; le récepteur de l'antigène des lymphocytes T (TcR) reconnaît le complexe peptide antigénique-CMH exprimé à la surface des cellules présentatrices. 2, record 10, French, - r%C3%A9cepteur%20immunologique
Record 10, Spanish
Record 10, Campo(s) temático(s)
- Inmunología
Record 10, Main entry term, Spanish
- inmunorreceptor
1, record 10, Spanish, inmunorreceptor
correct, masculine noun
Record 10, Abbreviations, Spanish
Record 10, Synonyms, Spanish
Record 10, Textual support, Spanish
Record 11 - internal organization data 2007-01-16
Record 11, English
Record 11, Subject field(s)
- Immunology
Record 11, Main entry term, English
- MHC restriction 1, record 11, English, MHC%20restriction
Record 11, Abbreviations, English
Record 11, Synonyms, English
Record 11, Textual support, English
Record number: 11, Textual support number: 1 DEF
A characteristic of many immune reactions in which cells cooperate most effectively with other cells sharing an MHC haplotype. 2, record 11, English, - MHC%20restriction
Record number: 11, Textual support number: 2 DEF
The phenomenon of certain cell-cell interactions in the immune response occurring only between MHC haploidentical cells. Helper T cells are activated only when the antigen is "seen" in conjunction with self class II MHC antigens(Ia antigens in mice, HLA-DR antigens in humans) antigens(K or D antigens in mice, HLA-A,-B, or-C antigens in humans). 3, record 11, English, - MHC%20restriction
Record 11, French
Record 11, Domaine(s)
- Immunologie
Record 11, Main entry term, French
- cytotoxicité restreinte au CMH
1, record 11, French, cytotoxicit%C3%A9%20restreinte%20au%20CMH
feminine noun
Record 11, Abbreviations, French
Record 11, Synonyms, French
- restriction au CMH 2, record 11, French, restriction%20au%20CMH
feminine noun
Record 11, Textual support, French
Record number: 11, Textual support number: 1 CONT
Réactions antivirales; la restriction au CMH : les virus peuvent aussi provoquer l'apparition de lymphocytes T cytotoxiques. [...] Une particularité essentielle de ces réactions cytotoxiques antivirales tient [...] à la nécessité d'une compatibilité au CMH entre la cellule infectée qui a initialement servi à sensibiliser le précurseur des lymphocytes T cytotoxiques et la cellule cible infectée à laquelle le lymphocyte T cytotoxique est confronté au cours de la phase de cytotoxicité. 1, record 11, French, - cytotoxicit%C3%A9%20restreinte%20au%20CMH
Record 11, Spanish
Record 11, Campo(s) temático(s)
- Inmunología
Record 11, Main entry term, Spanish
- restricción del CMH
1, record 11, Spanish, restricci%C3%B3n%20del%20CMH
correct, feminine noun
Record 11, Abbreviations, Spanish
Record 11, Synonyms, Spanish
Record 11, Textual support, Spanish
Record 12 - internal organization data 2006-05-18
Record 12, English
Record 12, Subject field(s)
- Immunology
Record 12, Main entry term, English
- agretope 1, record 12, English, agretope
Record 12, Abbreviations, English
Record 12, Synonyms, English
Record 12, Textual support, English
Record number: 12, Textual support number: 1 DEF
The portion of an antigen or antigen fragment which interacts with an MHC molecule. 1, record 12, English, - agretope
Record 12, French
Record 12, Domaine(s)
- Immunologie
Record 12, Main entry term, French
- agrétope
1, record 12, French, agr%C3%A9tope
masculine noun
Record 12, Abbreviations, French
Record 12, Synonyms, French
Record 12, Textual support, French
Record number: 12, Textual support number: 1 DEF
Portion d'un antigène ou d'un fragment antigénique qui lie avec la molécule du CMH (complexe majeur d'histocompatibilité). 2, record 12, French, - agr%C3%A9tope
Record number: 12, Textual support number: 1 OBS
Déterminant de l'antigène. 3, record 12, French, - agr%C3%A9tope
Record 12, Spanish
Record 12, Campo(s) temático(s)
- Inmunología
Record 12, Main entry term, Spanish
- agretopo
1, record 12, Spanish, agretopo
correct, masculine noun
Record 12, Abbreviations, Spanish
Record 12, Synonyms, Spanish
Record 12, Textual support, Spanish
Record 13 - internal organization data 2006-05-08
Record 13, English
Record 13, Subject field(s)
- Immunology
Record 13, Main entry term, English
- proteasome
1, record 13, English, proteasome
correct
Record 13, Abbreviations, English
Record 13, Synonyms, English
- multicatalytic protease complex 1, record 13, English, multicatalytic%20protease%20complex
correct
- MCP 1, record 13, English, MCP
correct
- MCP 1, record 13, English, MCP
Record 13, Textual support, English
Record number: 13, Textual support number: 1 DEF
Multi-subunit proteinase involved in the breakdown of both misfolded and regulatory proteins, and that is believed to generate peptides which associate with MHC class I molecules. 1, record 13, English, - proteasome
Record 13, French
Record 13, Domaine(s)
- Immunologie
Record 13, Main entry term, French
- protéasome
1, record 13, French, prot%C3%A9asome
correct
Record 13, Abbreviations, French
Record 13, Synonyms, French
Record 13, Textual support, French
Record number: 13, Textual support number: 1 DEF
Complexe catalytique formé de multiples sous-unités, dont l'activité protéase est impliquée dans la génération des peptides qui se lient aux molécules du CMH. 1, record 13, French, - prot%C3%A9asome
Record 13, Spanish
Record 13, Campo(s) temático(s)
- Inmunología
Record 13, Main entry term, Spanish
- proteasoma
1, record 13, Spanish, proteasoma
correct, masculine noun
Record 13, Abbreviations, Spanish
Record 13, Synonyms, Spanish
Record 13, Textual support, Spanish
Record 14 - internal organization data 2006-05-08
Record 14, English
Record 14, Subject field(s)
- Genetics
Record 14, Main entry term, English
- antigenic receptor
1, record 14, English, antigenic%20receptor
correct
Record 14, Abbreviations, English
Record 14, Synonyms, English
Record 14, Textual support, English
Record number: 14, Textual support number: 1 CONT
The T cell antigen receptor is the key to the cells activity. The receptor consists of one alpha-chain protein and one beta-chain protein. The receptor is fussy : it can bind only with a single type of antigen, which must be held by specific major histocompatibility(MHC) proteins on the surface of cells. 1, record 14, English, - antigenic%20receptor
Record 14, French
Record 14, Domaine(s)
- Génétique
Record 14, Main entry term, French
- récepteur antigénique
1, record 14, French, r%C3%A9cepteur%20antig%C3%A9nique
correct
Record 14, Abbreviations, French
Record 14, Synonyms, French
Record 14, Textual support, French
Record 14, Spanish
Record 14, Campo(s) temático(s)
- Genética
Record 14, Main entry term, Spanish
- receptor antigénico
1, record 14, Spanish, receptor%20antig%C3%A9nico
correct, masculine noun
Record 14, Abbreviations, Spanish
Record 14, Synonyms, Spanish
Record 14, Textual support, Spanish
Record 15 - internal organization data 2006-05-05
Record 15, English
Record 15, Subject field(s)
- Immunology
Record 15, Main entry term, English
- histotope 1, record 15, English, histotope
Record 15, Abbreviations, English
Record 15, Synonyms, English
Record 15, Textual support, English
Record number: 15, Textual support number: 1 DEF
This is the part of the MHC molecule which is recognized by the T cell. 1, record 15, English, - histotope
Record 15, French
Record 15, Domaine(s)
- Immunologie
Record 15, Main entry term, French
- histotope
1, record 15, French, histotope
masculine noun
Record 15, Abbreviations, French
Record 15, Synonyms, French
Record 15, Textual support, French
Record number: 15, Textual support number: 1 CONT
[...] les animaux NR ne répondent pas à l'antigène parce que leurs cellules sont incapables de reconnaître le complexe formé par la molécule d'antigène (ou épitope) avec la molécule d'antigène de classe II autologue (ou histotope). 1, record 15, French, - histotope
Record 15, Spanish
Record 15, Campo(s) temático(s)
- Inmunología
Record 15, Main entry term, Spanish
- histotopo
1, record 15, Spanish, histotopo
correct, masculine noun
Record 15, Abbreviations, Spanish
Record 15, Synonyms, Spanish
Record 15, Textual support, Spanish
Record 16 - internal organization data 2006-05-05
Record 16, English
Record 16, Subject field(s)
- Genetics
Record 16, Main entry term, English
- immune-response gene 1, record 16, English, immune%2Dresponse%20gene
Record 16, Abbreviations, English
Record 16, Synonyms, English
- immune response gene 2, record 16, English, immune%20response%20gene
- Ir gene 3, record 16, English, Ir%20gene
- IR gene 4, record 16, English, IR%20gene
Record 16, Textual support, English
Record number: 16, Textual support number: 1 DEF
A structural gene in the MHC that exerts a regulatory role on the immune response. 5, record 16, English, - immune%2Dresponse%20gene
Record 16, French
Record 16, Domaine(s)
- Génétique
Record 16, Main entry term, French
- gène de la réponse immunitaire
1, record 16, French, g%C3%A8ne%20de%20la%20r%C3%A9ponse%20immunitaire
masculine noun
Record 16, Abbreviations, French
Record 16, Synonyms, French
- gène de réponse immunitaire 2, record 16, French, g%C3%A8ne%20de%20r%C3%A9ponse%20immunitaire
masculine noun
- gène Ir 2, record 16, French, g%C3%A8ne%20Ir
masculine noun
- gène IR 3, record 16, French, g%C3%A8ne%20IR
masculine noun
Record 16, Textual support, French
Record number: 16, Textual support number: 1 CONT
Le processus par lequel les gènes interfèrent, pour provoquer ou prévenir le diabète, est loin d'être clair. L'une des hypothèses avancées provient des travaux de Hugh McDevitt, de l'Université de Stanford et de Baruj Benacerraf, de la Faculté de médecine de Harvard. Ils ont découvert que chez la souris, des gènes spécifiques contrôlent les gènes de la réponse immunitaire (RI) et que ces gènes sont localisés dans la même portion du chromosome que ceux correspondant aux principaux antigènes d'histocompatibilité de la souris. 1, record 16, French, - g%C3%A8ne%20de%20la%20r%C3%A9ponse%20immunitaire
Record 16, Spanish
Record 16, Campo(s) temático(s)
- Genética
Record 16, Main entry term, Spanish
- gen de respuesta inmunitaria
1, record 16, Spanish, gen%20de%20respuesta%20inmunitaria
correct, masculine noun
Record 16, Abbreviations, Spanish
Record 16, Synonyms, Spanish
- gen Ir 1, record 16, Spanish, gen%20Ir
correct, masculine noun
Record 16, Textual support, Spanish
Record 17 - internal organization data 2005-08-11
Record 17, English
Record 17, Subject field(s)
- Immunology
Record 17, Main entry term, English
- immunologic enhancement
1, record 17, English, immunologic%20enhancement
correct
Record 17, Abbreviations, English
Record 17, Synonyms, English
- enhancement 2, record 17, English, enhancement
correct
Record 17, Textual support, English
Record number: 17, Textual support number: 1 DEF
Increase growth and survival of allogenic organ or tumour transplants in a host which has antibody to the organ graft or tumour. 3, record 17, English, - immunologic%20enhancement
Record number: 17, Textual support number: 1 OBS
Enhancement is attributed to the presence of antibodies to class 2 MHC antigens on potential antigen-presenting cells within the graft, thereby inhibiting effective antigen presentation. 3, record 17, English, - immunologic%20enhancement
Record 17, French
Record 17, Domaine(s)
- Immunologie
Record 17, Main entry term, French
- facilitation
1, record 17, French, facilitation
correct, feminine noun
Record 17, Abbreviations, French
Record 17, Synonyms, French
- phénomène de facilitation 2, record 17, French, ph%C3%A9nom%C3%A8ne%20de%20facilitation
masculine noun
Record 17, Textual support, French
Record number: 17, Textual support number: 1 DEF
Phénomène par lequel un anticorps dit «facilitant» protège l'antigène correspondant et l'intégrité des structures cytologiques qui le portent, en empêchant cet antigène d'induire ou de subir une réaction immunitaire de rejet. 2, record 17, French, - facilitation
Record 17, Spanish
Record 17, Campo(s) temático(s)
- Inmunología
Record 17, Main entry term, Spanish
- fenómeno de facilitación
1, record 17, Spanish, fen%C3%B3meno%20de%20facilitaci%C3%B3n
masculine noun
Record 17, Abbreviations, Spanish
Record 17, Synonyms, Spanish
Record 17, Textual support, Spanish
Record 18 - internal organization data 1997-08-29
Record 18, English
Record 18, Subject field(s)
- Genetics
Record 18, Main entry term, English
- immunotargeting
1, record 18, English, immunotargeting
correct
Record 18, Abbreviations, English
Record 18, Synonyms, English
Record 18, Textual support, English
Record number: 18, Textual support number: 1 CONT
As well, we are continuing to explore a new approach to subunit vaccine design introduced by our laboratory a number of years ago(see Carayanniotis and Barber(1987) Nature 327, 59). By conjugation of purified protein or synthetic peptide antigens to monoclonal antibodies specific for defined cell surface determinants in vivo(e. g. class II MHC), it is possible to induce an effective antibody response to the "targeted" antigen(for recent data see Skea and Barber(1993) J. Immunol. 151, 3557). We are currently using recombinant DNA approaches to "engineer" specific B-and T-cell epitopes into selected sites on immunotargeting antibodies. In addition to our work using influenza virus as a model, we are also studying conserved B-and T-cell epitopes from HIV in order to develop a candidate AIDS vaccine. 2, record 18, English, - immunotargeting
Record 18, French
Record 18, Domaine(s)
- Génétique
Record 18, Main entry term, French
- ciblage immunologique
1, record 18, French, ciblage%20immunologique
proposal, masculine noun
Record 18, Abbreviations, French
Record 18, Synonyms, French
Record 18, Textual support, French
Record 18, Spanish
Record 18, Textual support, Spanish
Record 19 - internal organization data 1993-03-24
Record 19, English
Record 19, Subject field(s)
- Immunology
Record 19, Main entry term, English
- associate recognition 1, record 19, English, associate%20recognition
Record 19, Abbreviations, English
Record 19, Synonyms, English
Record 19, Textual support, English
Record number: 19, Textual support number: 1 DEF
In this hypothesis the processed antigen becomes physically associated with the MHC product and the combined unit is then recognized by a single receptor molecule. 1, record 19, English, - associate%20recognition
Record 19, French
Record 19, Domaine(s)
- Immunologie
Record 19, Main entry term, French
- modèle d'intimité
1, record 19, French, mod%C3%A8le%20d%27intimit%C3%A9
masculine noun
Record 19, Abbreviations, French
Record 19, Synonyms, French
Record 19, Textual support, French
Record number: 19, Textual support number: 1 CONT
Alors que les modèles anciens (modèle d'intimité, modèle à deux récepteurs, modèle du soi altéré) incorporent la notion de reconnaissance de l'«antigène» du CMH (complexe majeur d'histocompatibilité) ou de sa coreconnaissance avec l'antigène nominal par le lymphocyte T, le modèle du soi peptidique renverse la perspective. 1, record 19, French, - mod%C3%A8le%20d%27intimit%C3%A9
Record 19, Spanish
Record 19, Textual support, Spanish
Record 20 - internal organization data 1993-03-24
Record 20, English
Record 20, Subject field(s)
- Lymphatic System
Record 20, Main entry term, English
- CD8 molecule 1, record 20, English, CD8%20molecule
Record 20, Abbreviations, English
Record 20, Synonyms, English
Record 20, Textual support, English
Record number: 20, Textual support number: 1 CONT
Recent studies have shown that the CD4 molecule does indeed have a weak affinity for MHC class II molecules. These observations support the idea that antigen recognition by T cells involves the formation of a complex of T cell antigen receptor and CD4 or CD8 on the T cell which recognizes antigen plus MHC on another cell. 1, record 20, English, - CD8%20molecule
Record 20, French
Record 20, Domaine(s)
- Système lymphatique
Record 20, Main entry term, French
- molécule CD8
1, record 20, French, mol%C3%A9cule%20CD8
feminine noun
Record 20, Abbreviations, French
Record 20, Synonyms, French
Record 20, Textual support, French
Record number: 20, Textual support number: 1 CONT
CD4 et CD8. Les cellules T matures des organes lymphoïdes périphériques expriment l'une ou l'autre de ces deux glycoprotéines, qui déterminent la classe de molécules de CMH reconnue en association avec l'antigène : classe II pour CD4 et classe I pour CD8. De poids moléculaires respectifs de 55 kDA et 32 kDA, elles appartiennent à la superfamille des immunoglobulines. Leur rôle est incertain : augmentation de l'avidité des récepteurs [alpha][bêta] ayant une faible avidité initiale, interaction avec les molécules de CMH, activation cellulaire? 1, record 20, French, - mol%C3%A9cule%20CD8
Record 20, Spanish
Record 20, Textual support, Spanish
Record 21 - internal organization data 1993-03-24
Record 21, English
Record 21, Subject field(s)
- Immunology
Record 21, Main entry term, English
- independent recognition 1, record 21, English, independent%20recognition
Record 21, Abbreviations, English
Record 21, Synonyms, English
Record 21, Textual support, English
Record number: 21, Textual support number: 1 DEF
This hypothesis proposes the existence of separate receptors on the T cell for antigen and the MHC molecule. 1, record 21, English, - independent%20recognition
Record 21, French
Record 21, Domaine(s)
- Immunologie
Record 21, Main entry term, French
- modèle à deux récepteurs
1, record 21, French, mod%C3%A8le%20%C3%A0%20deux%20r%C3%A9cepteurs
masculine noun
Record 21, Abbreviations, French
Record 21, Synonyms, French
Record 21, Textual support, French
Record number: 21, Textual support number: 1 CONT
Alors que les modèles anciens (modèle d'intimité, modèle à deux récepteurs, modèle du soi altéré) incorporent la notion de reconnaissance de l'«antigène» du CMH (complexe majeur d'histocompatibilité) ou de sa coreconnaissance avec l'antigène nominal par le lymphocyte T, le modèle du soi peptidique renverse la perspective. 1, record 21, French, - mod%C3%A8le%20%C3%A0%20deux%20r%C3%A9cepteurs
Record 21, Spanish
Record 21, Textual support, Spanish
Record 22 - internal organization data 1993-03-24
Record 22, English
Record 22, Subject field(s)
- Immunology
Record 22, Main entry term, English
- privileged tissue 1, record 22, English, privileged%20tissue
Record 22, Abbreviations, English
Record 22, Synonyms, English
Record 22, Textual support, English
Record number: 22, Textual support number: 1 CONT
Transplantation... Some allogeneic tissues induce only weak immune reactions, eg. liver. One explanation is that the privileged tissues express relatively few MHC antigens on their cell surfaces. 1, record 22, English, - privileged%20tissue
Record 22, French
Record 22, Domaine(s)
- Immunologie
Record 22, Main entry term, French
- tissu privilégié
1, record 22, French, tissu%20privil%C3%A9gi%C3%A9
masculine noun
Record 22, Abbreviations, French
Record 22, Synonyms, French
Record 22, Textual support, French
Record number: 22, Textual support number: 1 CONT
Les tissus privilégiés sont des tissus non vascularisés particulièrement résistants aux phénomènes de rejet. Ainsi, les cartilages, recouverts de sialomucine, ne sont pas rejetés quand ils sont greffés à des hôtes allogéniques. 1, record 22, French, - tissu%20privil%C3%A9gi%C3%A9
Record 22, Spanish
Record 22, Textual support, Spanish
Record 23 - internal organization data 1993-03-24
Record 23, English
Record 23, Subject field(s)
- Immunology
Record 23, Main entry term, English
- peptidic self 1, record 23, English, peptidic%20self
Record 23, Abbreviations, English
Record 23, Synonyms, English
Record 23, Textual support, English
Record number: 23, Textual support number: 1 CONT
The concept that selected peptides derived from self proteins are permanently presented by class I and class II MHYC molecules is the basis of the peptidic self model. Its numerous implications include :(a) a definition of the self(versus non-self), as the set of peptides derived from self proteins and selected by the MHC molecules of the individual;(b) the prediction of the existence of the so-called "idiopeptides" which possibly constitute a new class of regulatory elements in the immune system, suggesting an "idiopeptidic" network;.... 1, record 23, English, - peptidic%20self
Record 23, French
Record 23, Domaine(s)
- Immunologie
Record 23, Main entry term, French
- soi peptidique
1, record 23, French, soi%20peptidique
masculine noun
Record 23, Abbreviations, French
Record 23, Synonyms, French
Record 23, Textual support, French
Record number: 23, Textual support number: 1 CONT
Le «soi», du point de vue du système immunitaire, serait défini par un ensemble de peptides dérivés des protéines cellulaires et présentés aux lymphocytes T dans le contexte des molécules HLA chez l'homme (ou H2 chez la souris). Cette proposition générale, qui fonde le modèle du soi peptidique, conduit à distinguer un «soi somatique», représenté par des peptides dérivés des protéines générales, et un «soi immunologique» dont le support serait des «idioptides» [...] Les lymphocytes T seraient tolérants au «soi somatique» et éventuellement réactifs au «soi immunologique», ce qui pourrait être à la base d'un réseau idiopeptidique. 1, record 23, French, - soi%20peptidique
Record 23, Spanish
Record 23, Textual support, Spanish
Record 24 - internal organization data 1993-03-24
Record 24, English
Record 24, Subject field(s)
- Immunology
Record 24, Main entry term, English
- CD4 molecule 1, record 24, English, CD4%20molecule
Record 24, Abbreviations, English
Record 24, Synonyms, English
Record 24, Textual support, English
Record number: 24, Textual support number: 1 CONT
Recent studies have shown that the CD4 molecule does indeed have a weak affinity for MHC class II molecules. These observations support the idea that antigen recognition by T cells involves the formation of a complex of T cell antigen receptor and CD4 or CD8 on the T cell which recognizes antigen plus MHC on another cell. 1, record 24, English, - CD4%20molecule
Record 24, French
Record 24, Domaine(s)
- Immunologie
Record 24, Main entry term, French
- molécule CD4
1, record 24, French, mol%C3%A9cule%20CD4
feminine noun
Record 24, Abbreviations, French
Record 24, Synonyms, French
Record 24, Textual support, French
Record number: 24, Textual support number: 1 CONT
CD4 et CD8. Les cellules T matures des organes lymphoïdes périphériques expriment l'une ou l'autre de ces deux glycoprotéines, qui déterminent la classe de molécules de CMH reconnue en association avec l'antigène : classe II pour CD4 et classe I pour CD8. De poids moléculaires respectifs de 55 kDA et 32 kDA, elles appartiennent à la superfamille des immunoglobulines. Leur rôle est incertain : augmentation de l'avidité des récepteurs [bêta] ayant une faible avidité initiale, interaction avec les molécules de CMH, activation cellulaire. 1, record 24, French, - mol%C3%A9cule%20CD4
Record 24, Spanish
Record 24, Textual support, Spanish
Record 25 - internal organization data 1993-03-24
Record 25, English
Record 25, Subject field(s)
- Immunology
Record 25, Main entry term, English
- class III MHC molecule 1, record 25, English, class%20III%20MHC%20molecule
Record 25, Abbreviations, English
Record 25, Synonyms, English
Record 25, Textual support, English
Record number: 25, Textual support number: 1 CONT
Three major classes of molecule coded within the MHC. Class I molecules have one MHC encoded peptide associated with B2-microglobuline. Class II molecules have two MHC encoded peptides which are non-covalently associated, and class III molecules are other molecules including complement components. 2, record 25, English, - class%20III%20MHC%20molecule
Record 25, French
Record 25, Domaine(s)
- Immunologie
Record 25, Main entry term, French
- molécule CMH de classe III
1, record 25, French, mol%C3%A9cule%20CMH%20de%20classe%20III
feminine noun
Record 25, Abbreviations, French
Record 25, Synonyms, French
Record 25, Textual support, French
Record number: 25, Textual support number: 1 CONT
Les trois classes majeures de molécules codées par le CMH. [...] Les molécules de classe III sont des composants du complément. 1, record 25, French, - mol%C3%A9cule%20CMH%20de%20classe%20III
Record 25, Spanish
Record 25, Textual support, Spanish
Record 26 - internal organization data 1993-03-23
Record 26, English
Record 26, Subject field(s)
- Immunology
Record 26, Main entry term, English
- altered self 1, record 26, English, altered%20self
Record 26, Abbreviations, English
Record 26, Synonyms, English
Record 26, Textual support, English
Record number: 26, Textual support number: 1 DEF
The concept that the combination of antigen and a self MHC molecule interacts with the immune system in the same way as an allogeneic MHC molecule. 1, record 26, English, - altered%20self
Record 26, French
Record 26, Domaine(s)
- Immunologie
Record 26, Main entry term, French
- soi modifié
1, record 26, French, soi%20modifi%C3%A9
masculine noun
Record 26, Abbreviations, French
Record 26, Synonyms, French
- soi altéré 2, record 26, French, soi%20alt%C3%A9r%C3%A9
masculine noun
Record 26, Textual support, French
Record number: 26, Textual support number: 1 DEF
Concept que la combinaison d'un antigène avec une molécule du MHC du soi interagit avec le système immunitaire de la même façon qu'une molécule allogénique du MHC. 1, record 26, French, - soi%20modifi%C3%A9
Record number: 26, Textual support number: 1 CONT
Alors que les modèles anciens (modèle d'intimité, modèle à deux récepteurs, modèle du soi altéré) incorporent la notion de reconnaissance de l'«antigène» du CMH (complexe majeur d'histocompatibilité) ou de sa coreconnaissance avec l'antigène nominal par le lymphocyte T, le modèle du soi peptidique renverse la perspective. 2, record 26, French, - soi%20modifi%C3%A9
Record 26, Spanish
Record 26, Textual support, Spanish
Record 27 - internal organization data 1993-03-23
Record 27, English
Record 27, Subject field(s)
- Immunology
Record 27, Main entry term, English
- peptide receptor 1, record 27, English, peptide%20receptor
Record 27, Abbreviations, English
Record 27, Synonyms, English
Record 27, Textual support, English
Record number: 27, Textual support number: 1 CONT
... T epitopes appear to be peptides derived from processed antigens and selectively presented by class I and class II molecules of the major histocompatibility complex(MHC). The latter can, therefore, be viewed as peptide receptors endowed with a certain specificity. The concept that selected peptides derived from self proteins are permanently presented by class I and class III MHC molecules is the basis of the peptidic self model. 1, record 27, English, - peptide%20receptor
Record 27, French
Record 27, Domaine(s)
- Immunologie
Record 27, Main entry term, French
- récepteur de peptides
1, record 27, French, r%C3%A9cepteur%20de%20peptides
masculine noun
Record 27, Abbreviations, French
Record 27, Synonyms, French
Record 27, Textual support, French
Record number: 27, Textual support number: 1 CONT
[...] les antigènes «étrangers» (qui suscitent une réponse immunitaire de type humoral ou cellulaire) subissent en général une dégradation intracellulaire, de sorte que ce sont des fragments d'antigènes (des peptides) qui sont reconnus par les cellules T; la fonction du complexe majeur d'histocompatibilité (CMH) est donc la suivante : ce sont, en fait, des récepteurs de peptides dotés d'une certaine spécificité, de telle sorte que différents antigènes du CMH lieront (c'est-à-dire présenteront) mieux certains peptides que d'autres. 1, record 27, French, - r%C3%A9cepteur%20de%20peptides
Record 27, Spanish
Record 27, Textual support, Spanish
Record 28 - internal organization data 1993-03-23
Record 28, English
Record 28, Subject field(s)
- Immunology
Record 28, Main entry term, English
- T cell antigen receptor 1, record 28, English, T%20cell%20antigen%20receptor
Record 28, Abbreviations, English
Record 28, Synonyms, English
Record 28, Textual support, English
Record number: 28, Textual support number: 1 DEF
Receptor on T cells that recognize specific foreign antigens and self MHC antigens; both must be seen simultaneously to trigger T cell activation; the T cell receptor has a constant and variable(antigen-finding) portion; the T cell antigen receptor has a [alpha] and [beta] chains which carry the idiotype(presumably the antigen binding site) and which are associated with the T3 molecule. 1, record 28, English, - T%20cell%20antigen%20receptor
Record 28, French
Record 28, Domaine(s)
- Immunologie
Record 28, Main entry term, French
- récepteur de reconnaissance de l'antigène des cellules T
1, record 28, French, r%C3%A9cepteur%20de%20reconnaissance%20de%20l%27antig%C3%A8ne%20des%20cellules%20T
masculine noun
Record 28, Abbreviations, French
Record 28, Synonyms, French
- site de reconnaissance 2, record 28, French, site%20de%20reconnaissance
masculine noun
- récepteur pour l'antigène du lymphocyte T 2, record 28, French, r%C3%A9cepteur%20pour%20l%27antig%C3%A8ne%20du%20lymphocyte%20T
masculine noun
Record 28, Textual support, French
Record number: 28, Textual support number: 1 CONT
Récepteurs de reconnaissance de l'antigène des cellules T. [...] Il existe à la surface des cellules T des récepteurs spécifiques pour l'antigène, analogues à de nombreux égards aux récepteurs immunologiques des cellules B : spécificité pour l'antigène, partie variable assurant la spécificité et partie constante, homologie de structure primaire et d'organisation génétique, distribution clonale. 1, record 28, French, - r%C3%A9cepteur%20de%20reconnaissance%20de%20l%27antig%C3%A8ne%20des%20cellules%20T
Record 28, Spanish
Record 28, Textual support, Spanish
Record 29 - internal organization data 1993-03-23
Record 29, English
Record 29, Subject field(s)
- Immunology
Record 29, Main entry term, English
- T4 cell surface marker 1, record 29, English, T4%20cell%20surface%20marker
Record 29, Abbreviations, English
Record 29, Synonyms, English
- CD4 T cell surface marker 1, record 29, English, CD4%20T%20cell%20surface%20marker
Record 29, Textual support, English
Record number: 29, Textual support number: 1 CONT
T(OKT) antigens are human T cell surface markers.... T4(CD4), present on helper cells, is involved in MHC class 2 restricted interactions. 1, record 29, English, - T4%20cell%20surface%20marker
Record 29, French
Record 29, Domaine(s)
- Immunologie
Record 29, Main entry term, French
- récepteur T4
1, record 29, French, r%C3%A9cepteur%20T4
masculine noun
Record 29, Abbreviations, French
Record 29, Synonyms, French
- récepteur CD4 1, record 29, French, r%C3%A9cepteur%20CD4
masculine noun
Record 29, Textual support, French
Record number: 29, Textual support number: 1 DEF
Récepteur des molécules de la classe II du complexe majeur d'histocompatibilité (présent à la surface des lymphocytes T). 1, record 29, French, - r%C3%A9cepteur%20T4
Record 29, Spanish
Record 29, Textual support, Spanish
Record 30 - internal organization data 1993-03-23
Record 30, English
Record 30, Subject field(s)
- Immunology
Record 30, Main entry term, English
- class I/II restriction 1, record 30, English, class%20I%2FII%20restriction
Record 30, Abbreviations, English
Record 30, Synonyms, English
Record 30, Textual support, English
Record number: 30, Textual support number: 1 DEF
The observation that immunologically active cells will only cooperate effectively when they share MHC haplotypes at either the class I or class II foci. 1, record 30, English, - class%20I%2FII%20restriction
Record 30, French
Record 30, Domaine(s)
- Immunologie
Record 30, Main entry term, French
- restriction aux molécules de classe I/II
1, record 30, French, restriction%20aux%20mol%C3%A9cules%20de%20classe%20I%2FII
feminine noun
Record 30, Abbreviations, French
Record 30, Synonyms, French
Record 30, Textual support, French
Record number: 30, Textual support number: 1 DEF
Observation que les molécules immunocompétentes collaborent efficacement entre elles seulement lorsqu'elles ont en commun des haplotypes soit de la classe I, soit de la classe II du CMH. 1, record 30, French, - restriction%20aux%20mol%C3%A9cules%20de%20classe%20I%2FII
Record 30, Spanish
Record 30, Textual support, Spanish
Record 31 - internal organization data 1993-03-23
Record 31, English
Record 31, Subject field(s)
- Immunology
Record 31, Main entry term, English
- non-specific suppression 1, record 31, English, non%2Dspecific%20suppression
Record 31, Abbreviations, English
Record 31, Synonyms, English
Record 31, Textual support, English
Record number: 31, Textual support number: 1 CONT
A regulatory group of T cells(T suppressors) are responsible for controlling the activity of T helper and B cells. Suppression is antigen-, idiotype-or non-specific. Antigen-specific suppression is often MHC restricted.... Suppression mediated by T cells is one mechanism by which the immune system could prevent the development of immune reactions to self molecules. Suppression is an active process and can be differentiated from tolerance by transferring the suppression with T cells. 1, record 31, English, - non%2Dspecific%20suppression
Record 31, French
Record 31, Domaine(s)
- Immunologie
Record 31, Main entry term, French
- suppression non spécifique de l'antigène
1, record 31, French, suppression%20non%20sp%C3%A9cifique%20de%20l%27antig%C3%A8ne
feminine noun
Record 31, Abbreviations, French
Record 31, Synonyms, French
Record 31, Textual support, French
Record number: 31, Textual support number: 1 CONT
Une suppression non spécifique de l'antigène peut être observée au cours de nombreuses réactions immunitaires à médiation humorale [...] ou cellulaire [...], toutes réactions faisant intervenir les cellules T. 1, record 31, French, - suppression%20non%20sp%C3%A9cifique%20de%20l%27antig%C3%A8ne
Record 31, Spanish
Record 31, Textual support, Spanish
Record 32 - internal organization data 1993-03-23
Record 32, English
Record 32, Subject field(s)
- Immunology
Record 32, Main entry term, English
- idiotype-specific suppression 1, record 32, English, idiotype%2Dspecific%20suppression
Record 32, Abbreviations, English
Record 32, Synonyms, English
Record 32, Textual support, English
Record number: 32, Textual support number: 1 CONT
A regulatory group of T cells(T suppressors) are responsible for controlling the activity of T helper and B cells. Suppression is antigen-, idiotype-or non-specific. Antigen-specific suppression is often MHC restricted.... Suppression mediated by T cells is one mechanism by which the immune system could prevent the development of immune reactions to self molecules. Suppression is an active process and can be differentiated from tolerance by transferring the suppression with T cells. 1, record 32, English, - idiotype%2Dspecific%20suppression
Record 32, French
Record 32, Domaine(s)
- Immunologie
Record 32, Main entry term, French
- suppression idiotypique
1, record 32, French, suppression%20idiotypique
feminine noun
Record 32, Abbreviations, French
Record 32, Synonyms, French
Record 32, Textual support, French
Record number: 32, Textual support number: 1 CONT
Suppression idiotypique. La réponse aux polysaccharides des streptocoques A fait intervenir des cellules Ts, qui sont apparemment analogues aux cellules Ts spécifiques d'allotypes [...]. L'injection d'anticorps anti-idiotypiques à des souris peut supprimer la synthèse des anticorps porteurs des spécificités idiotypiques correspondantes. 1, record 32, French, - suppression%20idiotypique
Record 32, Spanish
Record 32, Textual support, Spanish
Record 33 - internal organization data 1993-03-22
Record 33, English
Record 33, Subject field(s)
- Immunology
Record 33, Main entry term, English
- T8 cell surface marker 1, record 33, English, T8%20cell%20surface%20marker
Record 33, Abbreviations, English
Record 33, Synonyms, English
- CD8 T cell surface marker 1, record 33, English, CD8%20T%20cell%20surface%20marker
Record 33, Textual support, English
Record number: 33, Textual support number: 1 CONT
T(OKT) antigens are human T cell surface markers.... T8(CD8) is present on cytotoxic and suppressor T cells and is involved in MHC class 1 restricted interactions. 1, record 33, English, - T8%20cell%20surface%20marker
Record 33, French
Record 33, Domaine(s)
- Immunologie
Record 33, Main entry term, French
- récepteur T8
1, record 33, French, r%C3%A9cepteur%20T8
masculine noun
Record 33, Abbreviations, French
Record 33, Synonyms, French
- récepteur CD8 1, record 33, French, r%C3%A9cepteur%20CD8
masculine noun
Record 33, Textual support, French
Record number: 33, Textual support number: 1 DEF
Récepteur des molécules de la classe I du complexe majeur d'histocompatibilité (présent à la surface des lymphocytes T). 1, record 33, French, - r%C3%A9cepteur%20T8
Record 33, Spanish
Record 33, Textual support, Spanish
Record 34 - internal organization data 1993-03-21
Record 34, English
Record 34, Subject field(s)
- Immunology
Record 34, Main entry term, English
- CD4 marker 1, record 34, English, CD4%20marker
Record 34, Abbreviations, English
Record 34, Synonyms, English
Record 34, Textual support, English
Record number: 34, Textual support number: 1 CONT
CD markers : New designation for human lymphocyte surface protein recognized by antibodies. Some are identical to OKT antigens.... T4(CD4), present on helper cells, is involved in MHC class 2 restricted interactions. 1, record 34, English, - CD4%20marker
Record number: 34, Textual support number: 1 OBS
Formerly designated T4. 1, record 34, English, - CD4%20marker
Record 34, French
Record 34, Domaine(s)
- Immunologie
Record 34, Main entry term, French
- oritéube CD4
1, record 34, French, orit%C3%A9ube%20CD4
masculine noun
Record 34, Abbreviations, French
Record 34, Synonyms, French
- molécule CD4 2, record 34, French, mol%C3%A9cule%20CD4
feminine noun
Record 34, Textual support, French
Record number: 34, Textual support number: 1 CONT
La protéine CD4 a-t-elle un avenir dans le traitement du SIDA? Le marqueur de membrane CD4, caractéristique de certaines sous-populations de lymphocyte T (cellules accessoires ou helper) est le récepteur principal des virus du SIDA HIV-1 ET hiv-2; il se fixe spécifiquement à la glycoprotéine de surface gp 120 de ces virus. [...] cette molécule, sous une forme soluble, pourrait se lier aux virus et inhiber leur fixation au récepteur CD4 des cellules T, bloquant ainsi leur infectiosité. 1, record 34, French, - orit%C3%A9ube%20CD4
Record number: 34, Textual support number: 2 CONT
(Les virus HIV) pénètrent les cellules qui portent un récepteur spécifique à leur surface (la molécule CDA présente sur la surface des lymphocytes T auxiliaires et probablement des neurones). 2, record 34, French, - orit%C3%A9ube%20CD4
Record 34, Spanish
Record 34, Textual support, Spanish
Record 35 - internal organization data 1993-03-02
Record 35, English
Record 35, Subject field(s)
- Immunology
Record 35, Main entry term, English
- class I antigen
1, record 35, English, class%20I%20antigen
correct
Record 35, Abbreviations, English
Record 35, Synonyms, English
- class I MHC molecule 2, record 35, English, class%20I%20MHC%20molecule
Record 35, Textual support, English
Record number: 35, Textual support number: 1 DEF
(Each of) major histocompatibility antigens found on virtually every cell, human erythrocytes being the only notable exception; they are found on molecules consisting of two noncovalently bound chains. One on 44, 000-dalton polymorphic glycoprotein partially embedded in the cell membrane, is determined by an MHC gene(HLA-A,-B, or-C in humans) ;the other, [beta] 2-microglobulin, a 12, 000-dalton nonopolymorphic protein, is determined by a non-MHC gene. Class I antigens are the classic histocompatibility antigens recognized during graft rejection.... 3, record 35, English, - class%20I%20antigen
Record number: 35, Textual support number: 2 DEF
Histocompatibility antigen composed of two non-covalently associated, glycosylated polypeptides: a heavy chain of M. Wt. 44 000 and beta squared-microglobulin, M. Wt. 12 000. 4, record 35, English, - class%20I%20antigen
Record 35, French
Record 35, Domaine(s)
- Immunologie
Record 35, Main entry term, French
- antigène de classe I
1, record 35, French, antig%C3%A8ne%20de%20classe%20I
correct, masculine noun
Record 35, Abbreviations, French
Record 35, Synonyms, French
- CMH de classe I 2, record 35, French, CMH%20de%20classe%20I
Record 35, Textual support, French
Record number: 35, Textual support number: 1 CONT
Différentes approches ont permis de définir deux catégories d'antigènes d'histocompatibilité : les antigènes de classe I qui stimulent puis qui sont la cible de la réaction de lymphocytotoxicité due aux cellules T et les antigènes de classe II (...). (...) Les antigènes de classe I ont une distribution tissulaire ubiquitaire sur les cellules diploïdes (...). Les antigènes de classe I sont composés d'une chaîne lourde polymorphe (45 kDa) codée dans le CMH, associée à la [bêta]2-microglobuline non polymorphe qui est codée en dehors du CMH. 3, record 35, French, - antig%C3%A8ne%20de%20classe%20I
Record number: 35, Textual support number: 2 CONT
(...) la plupart des cellules cytotoxiques reconnaissent les antigènes viraux en association avec les antigènes de classe I ce qui conforte cette hypothèse, puisque ces antigènes sont présents sur la majorité des cellules. 4, record 35, French, - antig%C3%A8ne%20de%20classe%20I
Record 35, Spanish
Record 35, Textual support, Spanish
Record 36 - internal organization data 1993-02-19
Record 36, English
Record 36, Subject field(s)
- Immunology
Record 36, Main entry term, English
- class III antigen 1, record 36, English, class%20III%20antigen
Record 36, Abbreviations, English
Record 36, Synonyms, English
- class III MHC molecule 2, record 36, English, class%20III%20MHC%20molecule
- class III molecule 2, record 36, English, class%20III%20molecule
Record 36, Textual support, English
Record number: 36, Textual support number: 1 DEF
A term used to refer to nonhoistocompatibility antigens mapping in the major histocompatibility complex, e.g. the complement components C2, C4, and factor B. 1, record 36, English, - class%20III%20antigen
Record number: 36, Textual support number: 1 CONT
Class I/II/III MHC molecules. Three major classes of molecules coded within the MHC.... Class III molecules are other molecules including complement components. 2, record 36, English, - class%20III%20antigen
Record 36, French
Record 36, Domaine(s)
- Immunologie
Record 36, Main entry term, French
- antigène de classe III
1, record 36, French, antig%C3%A8ne%20de%20classe%20III
masculine noun
Record 36, Abbreviations, French
Record 36, Synonyms, French
- CMH de classe III 2, record 36, French, CMH%20de%20classe%20III
Record 36, Textual support, French
Record number: 36, Textual support number: 1 CONT
Des informations intéressantes ont aussi été obtenues à partir d'études démontrant l'association de certains facteurs du système complémentaire, parfois appelées antigènes de classe III, avec des antigènes HLA. Les polymorphismes du facteur B (Bf), du C2 et du C4 sont liés à celui des antigènes HLA. 1, record 36, French, - antig%C3%A8ne%20de%20classe%20III
Record 36, Spanish
Record 36, Textual support, Spanish
Record 37 - internal organization data 1993-02-13
Record 37, English
Record 37, Subject field(s)
- Immunology
Record 37, Main entry term, English
- beta 2-microglobuline 1, record 37, English, beta%202%2Dmicroglobuline
Record 37, Abbreviations, English
Record 37, Synonyms, English
Record 37, Textual support, English
Record number: 37, Textual support number: 1 DEF
A polypeptide which constitutes part of some membrane proteins including the class 1 MHC molecules. 1, record 37, English, - beta%202%2Dmicroglobuline
Record 37, French
Record 37, Domaine(s)
- Immunologie
Record 37, Main entry term, French
- bêta microglobuline
1, record 37, French, b%C3%AAta%20microglobuline
feminine noun
Record 37, Abbreviations, French
Record 37, Synonyms, French
- bêta 2-microglubuline 2, record 37, French, b%C3%AAta%202%2Dmicroglubuline
feminine noun
Record 37, Textual support, French
Record number: 37, Textual support number: 1 DEF
Polypeptide associé à un certain nombre de protéines de membranes, en particulier dans les molécules de classe 1 du CMH. 2, record 37, French, - b%C3%AAta%20microglobuline
Record number: 37, Textual support number: 1 CONT
Les molécules HLA de classe 1 sont exprimées sur toutes les cellules nucléées et sont composées d'une chaîne lourde de 44 Kd associée à une chaîne légère de 12 Kd, la bêta microglobuline (bêta 2m) dont le gène est situé sur le chromosome 15. 1, record 37, French, - b%C3%AAta%20microglobuline
Record 37, Spanish
Record 37, Textual support, Spanish
Record 38 - internal organization data 1993-02-10
Record 38, English
Record 38, Subject field(s)
- Immunology
Record 38, Main entry term, English
- education of T cells 1, record 38, English, education%20of%20T%20cells
Record 38, Abbreviations, English
Record 38, Synonyms, English
Record 38, Textual support, English
Record number: 38, Textual support number: 1 DEF
This is the process in which T cells learn to recognize antigen in association with self-MHC molecules, so that subsequently they can only be activated by antigens associated with the same MHC. Evidence for this was adduced using radiation chimaeras. 1, record 38, English, - education%20of%20T%20cells
Record 38, French
Record 38, Domaine(s)
- Immunologie
Record 38, Main entry term, French
- éducation des lymphocytes T
1, record 38, French, %C3%A9ducation%20des%20lymphocytes%20T
feminine noun
Record 38, Abbreviations, French
Record 38, Synonyms, French
Record 38, Textual support, French
Record number: 38, Textual support number: 1 CONT
Chez l'homme, comme chez la souris, l'immunisation in vivo ou l'éducation des lymphocytes T in vitro contre des antigènes viraux ou chimiques, présentés en association avec des cellules syngéniques, amène la production de cellules T cytotoxiques spécifiquement dirigées contre ces mêmes cellules syngéniques exprimant des antigènes viraux ou couplées à des haptènes. 1, record 38, French, - %C3%A9ducation%20des%20lymphocytes%20T
Record 38, Spanish
Record 38, Textual support, Spanish
Record 39 - internal organization data 1991-10-22
Record 39, English
Record 39, Subject field(s)
- Genetics
Record 39, Main entry term, English
- alpha-chain protein
1, record 39, English, alpha%2Dchain%20protein
correct
Record 39, Abbreviations, English
Record 39, Synonyms, English
Record 39, Textual support, English
Record number: 39, Textual support number: 1 CONT
The T cell antigen receptor is the key to the cells activity. The receptor consists of one alpha-chain protein and one beta-chain protein. The receptor is fussy : it can bind only with a single type of antigen, which must be held by specific major histocompatibility complex(MHC) proteins on the surface of cells. 1, record 39, English, - alpha%2Dchain%20protein
Record 39, French
Record 39, Domaine(s)
- Génétique
Record 39, Main entry term, French
- chaîne protéinique alpha
1, record 39, French, cha%C3%AEne%20prot%C3%A9inique%20alpha
correct, feminine noun
Record 39, Abbreviations, French
Record 39, Synonyms, French
Record 39, Textual support, French
Record 39, Spanish
Record 39, Textual support, Spanish
Record 40 - internal organization data 1991-10-21
Record 40, English
Record 40, Subject field(s)
- Cytology
Record 40, Main entry term, English
- discrete colony
1, record 40, English, discrete%20colony
correct
Record 40, Abbreviations, English
Record 40, Synonyms, English
Record 40, Textual support, English
Record number: 40, Textual support number: 1 CONT
Rat thymic cultures have been established in order to analyze the morpho-functional characteristics of thymic epithelial and non-epithelial cells in vitro. Stromal cultures, originating from implanted thymic fragments, consist of fibroblasts occupying most of the culture surface, epithelial cells forming discrete colonies, thymocytes and bone marrow-derived cells. Epithelial cells show a low class II MHC antigen expression, which is highly increased in semi-adherent cells, and do not interact with thymocytes. 2, record 40, English, - discrete%20colony
Record number: 40, Textual support number: 1 OBS
Tiré de : Immunology, 1991, 73(2), 165-172. 2, record 40, English, - discrete%20colony
Record number: 40, Textual support number: 2 OBS
discrete: having a separate or distinct identity. 3, record 40, English, - discrete%20colony
Record 40, French
Record 40, Domaine(s)
- Cytologie
Record 40, Main entry term, French
- colonie distincte
1, record 40, French, colonie%20distincte
proposal, feminine noun
Record 40, Abbreviations, French
Record 40, Synonyms, French
Record 40, Textual support, French
Record number: 40, Textual support number: 1 OBS
Équivalent approuvé par Docteur Josée Duhamel, biologiste au ministère de la Santé et du Bien-être du Canada. 1, record 40, French, - colonie%20distincte
Record 40, Spanish
Record 40, Textual support, Spanish
Record 41 - internal organization data 1991-07-22
Record 41, English
Record 41, Subject field(s)
- Biochemistry
Record 41, Main entry term, English
- idiopeptide
1, record 41, English, idiopeptide
correct
Record 41, Abbreviations, English
Record 41, Synonyms, English
Record 41, Textual support, English
Record number: 41, Textual support number: 1 CONT
The peptidic self model (...) idiopeptide. 2, record 41, English, - idiopeptide
Record number: 41, Textual support number: 2 CONT
The concept that selected peptides derived from self proteins are permanently presented by class I and class MHC molecules is the basis of peptidic self model. Its numerous implications include(...) the prediction of the existence of the so-called "idiopeptides" which possibly constitutes a new class of regulatory elements in the immune system suggesting an idiopeptidic network. 2, record 41, English, - idiopeptide
Record 41, French
Record 41, Domaine(s)
- Biochimie
Record 41, Main entry term, French
- idiopeptide
1, record 41, French, idiopeptide
correct, masculine noun
Record 41, Abbreviations, French
Record 41, Synonyms, French
Record 41, Textual support, French
Record number: 41, Textual support number: 1 CONT
A côté des peptides dérivés de protéines "banales", la présentation de peptides d'intérêt particulier est prédite : les fragments des molécules du CMH elles-mêmes, qui compliquent l'interprétation des situations allogéniques et les idiopeptides dérivés des régions variables des immunoglobulines (Ig) ou du TcR. Ces derniers ont été mis en évidence, présentés par les molécules du CMH de classe II des lymphocytes B et peuvent être reconnus par des clones de lymphocytes T. La généralité et l'importance fonctionnelle de la présentation d'idiopeptides dans la régulation (ou la pathologie) de la réponse immune est encore inconnue, mais c'est un domaine prometteur, qui laisse envisager de nouvelles voies thérapeutiques. 1, record 41, French, - idiopeptide
Record 41, Spanish
Record 41, Textual support, Spanish
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