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MHC GENE [2 records]
Record 1 - internal organization data 2006-05-05
Record 1, English
Record 1, Subject field(s)
- Genetics
Record 1, Main entry term, English
- immune-response gene 1, record 1, English, immune%2Dresponse%20gene
Record 1, Abbreviations, English
Record 1, Synonyms, English
- immune response gene 2, record 1, English, immune%20response%20gene
- Ir gene 3, record 1, English, Ir%20gene
- IR gene 4, record 1, English, IR%20gene
Record 1, Textual support, English
Record number: 1, Textual support number: 1 DEF
A structural gene in the MHC that exerts a regulatory role on the immune response. 5, record 1, English, - immune%2Dresponse%20gene
Record 1, French
Record 1, Domaine(s)
- Génétique
Record 1, Main entry term, French
- gène de la réponse immunitaire
1, record 1, French, g%C3%A8ne%20de%20la%20r%C3%A9ponse%20immunitaire
masculine noun
Record 1, Abbreviations, French
Record 1, Synonyms, French
- gène de réponse immunitaire 2, record 1, French, g%C3%A8ne%20de%20r%C3%A9ponse%20immunitaire
masculine noun
- gène Ir 2, record 1, French, g%C3%A8ne%20Ir
masculine noun
- gène IR 3, record 1, French, g%C3%A8ne%20IR
masculine noun
Record 1, Textual support, French
Record number: 1, Textual support number: 1 CONT
Le processus par lequel les gènes interfèrent, pour provoquer ou prévenir le diabète, est loin d'être clair. L'une des hypothèses avancées provient des travaux de Hugh McDevitt, de l'Université de Stanford et de Baruj Benacerraf, de la Faculté de médecine de Harvard. Ils ont découvert que chez la souris, des gènes spécifiques contrôlent les gènes de la réponse immunitaire (RI) et que ces gènes sont localisés dans la même portion du chromosome que ceux correspondant aux principaux antigènes d'histocompatibilité de la souris. 1, record 1, French, - g%C3%A8ne%20de%20la%20r%C3%A9ponse%20immunitaire
Record 1, Spanish
Record 1, Campo(s) temático(s)
- Genética
Record 1, Main entry term, Spanish
- gen de respuesta inmunitaria
1, record 1, Spanish, gen%20de%20respuesta%20inmunitaria
correct, masculine noun
Record 1, Abbreviations, Spanish
Record 1, Synonyms, Spanish
- gen Ir 1, record 1, Spanish, gen%20Ir
correct, masculine noun
Record 1, Textual support, Spanish
Record 2 - internal organization data 1993-03-02
Record 2, English
Record 2, Subject field(s)
- Immunology
Record 2, Main entry term, English
- class I antigen
1, record 2, English, class%20I%20antigen
correct
Record 2, Abbreviations, English
Record 2, Synonyms, English
- class I MHC molecule 2, record 2, English, class%20I%20MHC%20molecule
Record 2, Textual support, English
Record number: 2, Textual support number: 1 DEF
(Each of) major histocompatibility antigens found on virtually every cell, human erythrocytes being the only notable exception; they are found on molecules consisting of two noncovalently bound chains. One on 44, 000-dalton polymorphic glycoprotein partially embedded in the cell membrane, is determined by an MHC gene(HLA-A,-B, or-C in humans) ;the other, [beta] 2-microglobulin, a 12, 000-dalton nonopolymorphic protein, is determined by a non-MHC gene. Class I antigens are the classic histocompatibility antigens recognized during graft rejection.... 3, record 2, English, - class%20I%20antigen
Record number: 2, Textual support number: 2 DEF
Histocompatibility antigen composed of two non-covalently associated, glycosylated polypeptides: a heavy chain of M. Wt. 44 000 and beta squared-microglobulin, M. Wt. 12 000. 4, record 2, English, - class%20I%20antigen
Record 2, French
Record 2, Domaine(s)
- Immunologie
Record 2, Main entry term, French
- antigène de classe I
1, record 2, French, antig%C3%A8ne%20de%20classe%20I
correct, masculine noun
Record 2, Abbreviations, French
Record 2, Synonyms, French
- CMH de classe I 2, record 2, French, CMH%20de%20classe%20I
Record 2, Textual support, French
Record number: 2, Textual support number: 1 CONT
Différentes approches ont permis de définir deux catégories d'antigènes d'histocompatibilité : les antigènes de classe I qui stimulent puis qui sont la cible de la réaction de lymphocytotoxicité due aux cellules T et les antigènes de classe II (...). (...) Les antigènes de classe I ont une distribution tissulaire ubiquitaire sur les cellules diploïdes (...). Les antigènes de classe I sont composés d'une chaîne lourde polymorphe (45 kDa) codée dans le CMH, associée à la [bêta]2-microglobuline non polymorphe qui est codée en dehors du CMH. 3, record 2, French, - antig%C3%A8ne%20de%20classe%20I
Record number: 2, Textual support number: 2 CONT
(...) la plupart des cellules cytotoxiques reconnaissent les antigènes viraux en association avec les antigènes de classe I ce qui conforte cette hypothèse, puisque ces antigènes sont présents sur la majorité des cellules. 4, record 2, French, - antig%C3%A8ne%20de%20classe%20I
Record 2, Spanish
Record 2, Textual support, Spanish
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