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DONATH-LANDSTEINERS TEST [1 record]

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Record 1 2011-02-18

English

Subject field(s)
  • Diagnostic Procedures (Medicine)
  • Immunology
DEF

The diagnostic test for paroxysmal cold hemoglobinuria, in which complement-dependent antibodies are fixed to erythrocytes at low temperatures, and hemolysis occurs after warming to 37 degrees C.

Key term(s)
  • Donath-Landsteiner's test

French

Domaine(s)
  • Méthodes diagnostiques (Médecine)
  • Immunologie
DEF

Épreuve in vitro destinée au diagnostic de l'hémoglobinurie paroxystique a frigore grâce au pouvoir hémolysant du plasma sur ses propres hématies.

OBS

Hémoglobinurie paroxystique a frigore [...] Le diagnostic biologique repose actuellement moins sur le caractère biphasique de l'hémolysine décrite par Donath et Landsteiner [se fixant à froid et activant le complément à 37 degrés C], que sur les caractéristiques du test de Coombs de type complément ou IgG complément, avec présence dans le sérum d'un taux élevé d'anticorps IgG reconnaissant l'antigène P.

Spanish

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