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EMBRYONIC STEM CELL TECHNOLOGY [1 record]

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Record 1 2011-11-02

English

Subject field(s)
  • Embryology
  • Genetics
CONT

One block to large-animal engineering is that the most revolutionary technique in mouse transgenics- called embryonic stem cell technology- does not work in many other mammalian species. This means that while it is possible to produce the mouse of your dreams, selection in other animals is limited.

OBS

These studies demonstrate the feasibility of using embryonic stem cell technology to produce murine models of inherited human disorders. Characterization of mice bearing these disease-causing mutations is expected to provide novel insights into physiologic processes and provide new understanding of human pathologies.

French

Domaine(s)
  • Embryologie
  • Génétique
OBS

Nos travaux visent à caractériser les mécanismes moléculaires contrôlant le déroulement des stades précoces du développement lymphocytaire. Pour cela nous cherchons tout particulièrement à définir les éléments cis-régulateurs des recombinaisons VDJ et leurs modes d'action (i.e. comment ces éléments gouvernent l'accessibilité de la chromatine à la recombinase VDJ). Nous poursuivons ces objectifs à l'aide d'approches basées sur l'utilisation de substrats de recombinaison transgéniques et la manipulation génétique de cellules souches embryonnaires (cellules ES) murines.

Spanish

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