TERMIUM Plus®

The Government of Canada’s terminology and linguistic data bank.

PLEIOTROPIC RESISTANCE [1 record]

Record 1 2003-05-22

English

Subject field(s)
  • Pharmacology
CONT

Tumor cells may become generally resistant to a variety of cytotoxic drugs on the basis of decreased uptake or retention of the drugs. This form of resistance is called pleitropic or multidry resistance, and it is the major form of resistance to anthracyclines, vinea blaloids, and dactinomycin.

OBS

The gene which confers multidrug resistance has been cloned.

Key term(s)
  • multi-drug resistance

French

Domaine(s)
  • Pharmacologie
CONT

L'application des méthodes à l'étude du transport des antibiotiques a permis de mettre en évidence une sécrétion transépithéliale nette de sparfloxacine (Zagam) du milieu intérieur vers la lumière intestinale, cette sécrétion se faisant par l'intermédiaire de la protéine de résistance pléiotrope aux agents anti-cancéreux.

Spanish

Campo(s) temático(s)
  • Farmacología
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